Simvastatin

From WikiMD
Jump to navigation Jump to search

Simvastatin is a cholesterol lowering medication that is in the class of statin drugs that work by inhibiting a rate limiting step in the cholesterol synthesis in the liver called HMG co A reductase. The drug is popularly marketed as the brand name Zocor and helps in lowering the cholesterol and triglycerides.


Information about Simvastatin

Simvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury.

Mechanism of action of Simvastatin

Simvastatin (sim" va stat' in) is an orally available inhibitor of hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the major rate-limiting enzyme in cholesterol synthesis. Like other members of its class (the “statins”), simvastatin lowers total serum cholesterol and particularly low density lipoprotein (LDL) cholesterol concentrations, thereby reducing the risk of atherosclerosis and its complications – myocardial infarction and stroke.

FDA approval information for Simvastatin

Simvastatin was approved for use in the United States in 1991 and is still widely used with more than 40 million prescriptions being filled yearly.

Clinical use of Simvastatin

Current indications for simvastatin are hypercholesterolemia and reduction in risk for death from coronary, cerebrovascular and peripheral artery disease in patients with these diseases. Simvastatin is available generic forms and under the commercial name of Zocor in tablets of 5, 10, 20, 40 and 80 mg.

Dosage and administration for Simvastatin

The recommended dose is 5 to 80 mg daily based upon tolerability and lipid levels. Simvastatin is also available as a fixed combination with ezetimibe under the brand name Vytorin.

Side effects of Simvastatin

Common side effects include muscle cramps, joint aches, headache and weakness.

Lipid lowering medications

Cost and Coupons - Simvastatin

Reviews for Simvastatin


WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Articles on Simvastatin

This article is a stub. YOU can help Wikimd by expanding it!

Learn more about Simvastatin

Drug classes

WikiMD Resources for Simvastatin

Articles

Most recent articles

Most cited

Review articles

Articles on Simvastatin in N Eng J Med, Lancet, BMJ

Media Simvastatin

Powerpoint slides

Podcasts and MP3's

Videos

Evidence Based Medicine

Cochrane Collaboration

Clinical Trials

Ongoing Trials on Simvastatin

Trial results on Simvastatin

Clinical Trials on Simvastatin at Google

Books and news

Books on Simvastatin

Simvastatin in the news

Commentary Simvastatin

Blogs on Simvastatin

Patient Resources / Community

Patient resources

Discussion groups

Patient Handouts

Other resources

Social Media

Reddit
Quora.png
Pins
Instagram
YouTube videos
Flickr
Bing.png

W8MD Weight Loss, Sleep & MedSpa

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U |V | W | X | Y | Z

Ad. Tired of being overweight? W8MD's insurance weight loss program can HELP* | Lose weight King of Prussia, PA | Lose weight NYC | Lose weight NJ | Lose weight Philadelphia Advertise
Other languages:
English

Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer. * Individual results may vary for weight loss from our sponsors.

Our sponsors WikiMD is supported by W8MD weight loss, sleep and medical aesthetic centers.