Sotatercept
Sotatercept
Sotatercept (pronounced soh-tuh-ter-sept) is a novel investigational drug currently being studied for its potential use in the treatment of various anemia-related conditions.
Etymology
The name "Sotatercept" is derived from the drug's mechanism of action. It is a fusion protein that acts as a trap for certain proteins in the body, hence the suffix "-cept" which is commonly used in the names of receptor molecules or fusion proteins.
Mechanism of Action
Sotatercept works by binding to and inhibiting proteins in the transforming growth factor-beta (TGF-beta) superfamily, which are involved in the regulation of erythropoiesis, the process by which the body produces red blood cells. By inhibiting these proteins, Sotatercept can increase red blood cell production and potentially alleviate anemia.
Clinical Trials
Sotatercept has been studied in several clinical trials for conditions such as myelodysplastic syndromes (MDS), beta-thalassemia, and pulmonary arterial hypertension (PAH).
Related Terms
- Anemia: A condition characterized by a deficiency of red cells or of haemoglobin in the blood.
- Erythropoiesis: The process which produces red blood cells (erythrocytes).
- Transforming growth factor-beta (TGF-beta): A superfamily of proteins involved in the regulation of cell growth and differentiation.
- Myelodysplastic syndromes (MDS): A group of disorders caused by poorly formed blood cells or ones that don't work properly.
- Beta-thalassemia: A blood disorder that reduces the production of hemoglobin.
- Pulmonary arterial hypertension (PAH): A type of high blood pressure that affects the arteries in the lungs and the right side of the heart.
External links
- Medical encyclopedia article on Sotatercept
- Wikipedia's article - Sotatercept
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