Spindle pole body

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Spindle Pole Body

The Spindle Pole Body (SPB) (pronunciation: /ˈspɪndl poʊl ˈbɒdi/), is a crucial component of the cell cycle in yeast cells, functioning as the microtubule organizing center (MTOC).

Etymology

The term "Spindle Pole Body" is derived from its function and structure. "Spindle" refers to the shape of the structure during cell division, "Pole" indicates its position at the opposite ends of the cell, and "Body" signifies it as a distinct cellular entity.

Function

The SPB is responsible for the organization and nucleation of microtubules, which are essential for cell division. It plays a critical role in mitosis and meiosis, ensuring the correct segregation of chromosomes to daughter cells.

Structure

The SPB is a multi-layered structure composed of approximately 18 different proteins. It is embedded in the nuclear envelope during the entire cell cycle. The central layer, or the "central plaque", is inserted in the nuclear envelope. The "inner plaque" is oriented towards the nucleoplasm, and the "outer plaque" faces the cytoplasm.

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