Suramin sodium

Suramin Sodium

Suramin Sodium (pronunciation: soo-RAH-min SO-dee-um) is a medication primarily used for the treatment of human African trypanosomiasis (sleeping sickness) and onchocerciasis (river blindness). It is a polysulfonated naphthylurea that inhibits the growth of various cells.

Etymology

The name "Suramin" is derived from the German "Surena", a reference to the ancient Parthian general Surena. The compound was first synthesized by Oskar Dressel and Richard Kothe of Bayer in 1916.

Usage

Suramin Sodium is used in the treatment of Trypanosomiasis, a parasitic disease transmitted by the tsetse fly, and Onchocerciasis, a disease caused by infection with the parasitic worm Onchocerca volvulus, transmitted through the bites of blackflies.

Mechanism of Action

Suramin Sodium works by inhibiting the growth of the parasites that cause the diseases. It binds to the parasite's surface glycoproteins, blocking their interaction with components of the host's immune system.

Side Effects

Common side effects of Suramin Sodium include nausea, vomiting, diarrhea, abdominal pain, and rash. Severe side effects may include a decrease in blood cells, kidney problems, and allergic reactions.

Related Terms

• Trypanosomiasis
• Onchocerciasis
• Parasite
• Immune system
• Nausea
• Vomiting
• Diarrhea
• Rash

External links

• Medical encyclopedia article on Suramin sodium
• Wikipedia's article - Suramin sodium

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