Survivin

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Survivin

Survivin (/sərˈvaɪvɪn/) is a protein that in humans is encoded by the BIRC5 gene. It is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death.

Etymology

The term "Survivin" is derived from the English word "survive," reflecting the protein's role in inhibiting cell death and promoting cell survival.

Function

Survivin is involved in the control of cell division and the inhibition of apoptosis. It is expressed in a cell-cycle-dependent manner and interacts with the microtubules of the mitotic spindle to help segregate the chromosomes during mitosis.

Clinical significance

Survivin is expressed in many human cancers and is a target for new anticancer drug development. It is also involved in the regulation of angiogenesis, a process that is crucial for the growth and progression of solid tumors.

Related terms

  • Apoptosis: A form of programmed cell death that occurs in multicellular organisms.
  • Caspase: A family of protease enzymes playing essential roles in programmed cell death.
  • Microtubules: A component of the cytoskeleton, involved in maintaining the structure of the cell and cell division.
  • Mitotic spindle: A cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells.
  • Angiogenesis: The physiological process through which new blood vessels form from pre-existing vessels.

External links

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