TRAIL
TRAIL
TRAIL (pronounced /treɪl/), also known as TNF-related apoptosis-inducing ligand, is a protein that is involved in the induction of cell apoptosis.
Etymology
The term TRAIL is an acronym for TNF-Related Apoptosis-Inducing Ligand. It is part of the TNF (Tumor Necrosis Factor) superfamily, a group of proteins involved in the regulation of a wide range of biological processes including cell proliferation, differentiation, and apoptosis.
Function
TRAIL is a type of cytokine, a broad category of small proteins that are important in cell signaling. It is produced by most normal tissue cells but is especially expressed by immune cells such as T cells and Natural Killer (NK) cells. TRAIL induces apoptosis primarily in tumor cells by binding to certain death receptors on the cell surface, leading to the activation of the apoptotic pathway.
Related Terms
- Apoptosis: A form of programmed cell death that occurs in multicellular organisms.
- Cytokine: A type of protein that plays an important role in cell signaling.
- Immune cells: Cells that make up the immune system and help protect the body against harmful substances.
- TNF (Tumor Necrosis Factor): A cell signaling protein involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction.
See Also
External links
- Medical encyclopedia article on TRAIL
- Wikipedia's article - TRAIL
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