Taliglucerase alfa

From WikiMD
Jump to navigation Jump to search

Information about Taliglucerase alfa

Taliglucerase (tal" i gloo' ser ase) alfa was the third recombinant form of glucocerebrosidase approved for therapy of type 1 Gaucher disease. Taliglucerase is prepared in plant cell cultures transfected with the human glucocerebrosidase gene. Taliglucerase differs from the native enzyme by two amino acids at the N terminal and 7 amino acids at the C terminal end. It is glycosylated and the oligosaccharide chains have terminal mannose sugars, which increase its uptake by macrophages.

FDA approval information for Taliglucerase alfa

Taliglucerase was approved for use as enzyme replacement therapy for type 1 Gaucher disease in the United States in 2011. It is available as lyophilized powder in single use vials of 200 Units.

Dosage and administration for Taliglucerase alfa

The typical dose is 60 Units/kg every two weeks administered intravenously over 1 to 2 hours.

Side effects of Taliglucerase alfa

Side effects are not common and usually mild, but can include local infusion reactions, fatigue, headache, dizziness, abdominal pain, nausea, back pain, joint pain and fever. Rare, but reported severe adverse reactions include hypersensitivity reactions and anaphylaxis.

genetic disorder agents

cystic fibrosis agents

enzyme replacement therapy

glucosylceramide synthase inhibitors (substrate restriction therapy)

lysosomal acid lipase deficiency agents


homocystinuria agents

Huntington disease agents

Monoclonal Antibodies

Tyrosinemia Agents

Urea Cycle Disorder Agents

Hematologic Agents

Cost and Coupons - Taliglucerase alfa

Reviews for Taliglucerase alfa

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Articles on Taliglucerase alfa

This article is a stub. YOU can help Wikimd by expanding it!

Learn more about Taliglucerase alfa

Drug classes

Our sponsors:W8MD weight loss, sleep and medspa

WikiMD Resources for Taliglucerase alfa


Most recent articles

Most cited

Review articles

Articles on Taliglucerase alfa in N Eng J Med, Lancet, BMJ

Media Taliglucerase alfa

Powerpoint slides

Podcasts and MP3's


Evidence Based Medicine

Cochrane Collaboration

Clinical Trials

Ongoing Trials on Taliglucerase alfa

Trial results on Taliglucerase alfa

Clinical Trials on Taliglucerase alfa at Google

Books and news

Books on Taliglucerase alfa

Taliglucerase alfa in the news

Commentary Taliglucerase alfa

Blogs on Taliglucerase alfa

Patient Resources / Community

Patient resources

Discussion groups

Patient Handouts

Other resources

Social Media

YouTube videos

W8MD Weight Loss, Sleep & MedSpa

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U |V | W | X | Y | Z

W8MD logo

Ad. Tired of being overweight?. W8MD's insurance weight loss can HELP*

Lose weight King of Prussia, PA | Lose weight NYC | Lose weight NJ | Lose weight Philadelphia | Advertise

Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer. * Individual results may vary for weight loss from our sponsors.

Our sponsors WikiMD is supported by W8MD weight loss, sleep and medical aesthetic centers.