COVID-19 portal | Vitamin D | CDC | Vaccine | Keto | W8MD Diet

WikiMD is world's largest health encyclopedia with
28,560 pages, 3,992,076 edits & 34,330,898 views.

Unbiased health & wellness info for free & for all!

Taxanes

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Information about Taxanes

The taxanes or taxoids are a closely related group of antineoplastic agents that have a unique mechanism of action as inhibitors of mitosis and which are widely used in the therapy of ovarian, breast, lung, esophageal, prostate, bladder and head and neck cancers.  Three taxanes are in clinical use, paclitaxel (Taxol: 1992), docetaxel (Taxotere: 1996) and cabazitaxel (Jevtana: 2010). 

Mechanism of action of Taxanes

Paclitaxel was the first compound in this chemical group to be introducted into clinical use and was initially isolated from the bark of the Western yew tree.  Docetaxel is a semisynthetic analogue of paclitaxel and a derivative of extracts from needles of the European Yew (Taxus baccata) that has somewhat better pharmacokinetics and different side effects than paclitaxel.  Cabazitaxel is also a semisynthetic analogue of natural taxoids and was developed for its lack of affinity for P-glycoprotein, a common mediator of docetaxel reistance.  The taxanes are similar to the vinca alkaloids in that they bind to tubulin and cause inhibition of mitosis.  However, the taxanes bind at a different site than the vinca alkaloids and cause inhibition of mitosis by prevention of degradation of microtubules, rather than prevention of their assembly.  Three three taxanes are all given intravenously, usually every 1 to 3 weeks. 

Side effects of Taxanes

While taxanes have many side effects and can be associated with serum enzyme elevations during treatment, they have not been linked to idiosyncratic, clinically apparent liver injury with jaundice.  The few case reports of acute liver injury associated with taxanes (largely docetaxel) have occurred in patients with acute hypersensitivity reactions, sepsis or multiorgan failure.

Drug class for Taxanes

Drugs in the Subclass, Taxanes:  Cabazitaxel, Docetaxel, Paclitaxel 

Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ

 

Cost and Coupons - Taxanes

Reviews for Taxanes

Learn more about Taxanes

Latest research (Pubmed)

PubMed
Wikipedia

External links


edit 

WikiMD needs you!

This WikiMD article Taxanes is a stub.
If you are a healthcare professional familiar with the topic Taxanes, or
A subject matter expert or authority on Taxanes, you can help us.
About | Mission | Paid editors welcome!

Taxanes is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever!
Medicine: Health - Encyclopedia‏‎‏‎ - Topics‏‎ -‏‎ Diseases‏‎ - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity‏‎ - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*