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Information about Telmisartan

Telmisartan is an angiotensin II receptor blocker used in the therapy of hypertension.

Liver safety of Telmisartan

Telmisartan is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of acute liver injury.

Mechanism of action of Telmisartan

Telmisartan (tel" mi sar' tan) is an angiotensin II receptor blocker (ARB) used alone or in combination with other agents for therapy of hypertension. Telmisartan inhibits the renin-angiotensin system by blocking the angiotensin II type 1 receptor (AT1), which prevents the vasoconstriction and volume expansion induced by circulating angiotensin II which accounts for its potent antihypertensive activity.

FDA approval information for Telmisartan

Telmisartan was approved for use in the United States for treatment of hypertension in 1998 and indications were subsequently broadened to include reduction in risk of cardiovascular events in patients unable to take ACE inhibitors for this use.

Dosage and administration for Telmisartan

Telmisartan is available in 20, 40 and 80 mg tablets in generic forms and under the trade name Micardis. The typical dose of telmisartan in adults is 40 to 80 mg once daily, and it is used long term. Telmisartan is also available in fixed combinations with hydrochlorothiazide (Micardis HCT) and amlodipine (Twynsta).

Side effects of Telmisartan

Side effects are uncommon, but may include headache, dizziness, fatigue, cough, gastrointestinal upset and fetal toxicity. Many ARBs including telmisartan have been linked to rare cases of severe sprue-like enteropathy. The syndrome presents with severe diarrhea, weight loss and abdominal discomfort months to years after starting telmisartan. Intestinal biopsy shows villous flattening and atrophy similar to celiac disease. However, the diarrhea and symptoms do not improve with a gluten-free diet, but do resolve rapidly with stopping the angiotensin receptor blocker.

The common ARBS are the following:

Common ACE inhibitors include the following:

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