Teniposide

From WikiMD

Information about Teniposide

Irinotecan and topotecan are semisynthetic derivatives of the plant alkaloid camptothecin and are used as antineoplastic agents in the therapy of colorectal, ovarian and non-small cell lung cancer. 

Liver safety of Teniposide

Both irinotecan and topotecan are associated with an appreciable rate of serum enzyme elevations during therapy, and irinotecan has been implicated in causing steatohepatitis when given as cyclic anticancer therapy. 

Mechanism of action of Teniposide

Irinotecan (eye" ri noe tee' kan) and topotecan (toe" poe tee' kan) are semisynthetic derivatives of camptothecin, a plant alkaloid derived from the Chinese tree, Camptotheca acuminata.  Both drugs appear to act by blocking DNA topoisomerase I, which is responsible for relaxation of supercoiled double stranded DNA so that replication can proceed.  Topoisomerase I activity is particularly increased in cancer cells.  Irinotecan and topotecan have antineoplastic activity against colorectal, non-small cell lung and breast cancer in vivo and in vitro. 

FDA approval information for Teniposide

Irinotecan and topotecan were both approved for use in the United States in 1996 and continue to be used in oncology practice.  Current formal indications for irinotecan are advanced colorectal cancer alone or in combination with other antineoplastic agents (usually fluorouracil). 

Dosage and administration for Teniposide

Irinotecan is available generically and under the brand name Camptosar in 2, 5 and 15 mL vials of 20 mg/mL.  The typical dose varies is based upon body weight and is adjusted by whether it is used alone or in combination with other anticancer agents.  The approved indications for topotecan include advanced or metastatic ovarian and cervical cancer and small cell lung cancer (after failure of first line chemotherapy).  Topotecan is available in solution in 4 mg single dose vials generically and under the trade name Hycamtin.  The typical dose varies by indication and body weight. 

Side effects of Teniposide

Side effects of irinotecan and topotecan are similar and include bone marrow suppression, nausea, vomiting, abdominal pain, stomatitis, diarrhea, fatigue, hair loss and peripheral neuropathy.  Infusions of irinotecan can be associated with severe diarrhea which is typically delayed and is treated with loperamide.  Irinotecan also can cause an acute cholinergic syndrome marked by hypotension, diarrhea, sweating, lacrimation and fatigue, which is typically treated with atropine.

 

Cost and Coupons - Teniposide

Reviews for Teniposide

The article on Teniposide is a stub. YOU can help Wikimd by expanding it!

Medication resources

Learn more


edit 

WikiMD Resources - Teniposide


Help WikiMD:Join WikiMD as an an editor and help improve the page Teniposide or others.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*

Quick links: Medicine Portal | Encyclopedia‏‎‏‎ | Gray's Anatomy‏‎ | Topics‏‎ |‏‎ Diseases‏‎ | Drugs | Wellness | Obesity‏‎ | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="http://www.wikimd.org/wiki/Teniposide">Teniposide</a>

  • Individual results may vary for weight loss from our sponsors.