Terbinafine

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Information about Terbinafine

Terbinafine is an orally and topically active allylamine fungicidal agent which is used to treat superficial fungal infections of the skin and nails.

Liver safety of Terbinafine

Terbinafine has been clearly linked to rare instances of acute liver injury that can be severe and sometimes fatal.

Mechanism of action of Terbinafine

Terbinafine (ter' bin a feen) is a synthetic allylamine derivative that has potent activity against many dermatophytes that affect skin and nails, including Epidermophyton floccosum, Trichophyton mentagrophytes and Trichophyton rubrum. The antifungal activity of terbinafine is believed to be due to the selective inhibition of fungal squalene epoxidase, which increases squalene to toxic levels, thus killing the fungal cell.

FDA approval information for Terbinafine

Terbinafine was approved for use in the United States in a topical form in 1992 and as an oral antifungal agent in 1998. Topical terbinafine is available over-the-counter as a 1% cream or spray for treatment of dermatophyte infections of the skin (tinea pedis, cruris or corporis).

Dosage and administration for Terbinafine

Oral terbinafine is available by prescription only in tablets of 250 mg generically and under the brand name of Lamisal. Oral terbinafine is used in the therapy of onychomycosis or fungal infections of the fingernails or toenails (tinea unguium) typically in a dose of 250 mg once daily for 6 weeks (fingernails) or 12 weeks (toenails).

Side effects of Terbinafine

The most common side effects of terbinafine include gastrointestinal disturbances, headache, change in taste and rash.

The following drugs are antifungal agents:

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