Tetrabenazine

From WikiMD
Jump to navigation Jump to search

Information about Tetrabenazine

The vesicular monoamine transporter type 2 (VMAT2) inhibitors are agents that cause a depletion of neuroactive peptides such as dopamine in nerve terminals and are used to treat chorea due to neurodegenerative diseases (such as Huntington disease or Hungtington chorea) or dyskinesias due to neuroleptic medications (tardive dyskinesia). As of 2019, three VMAT2 inhibitors have become available in the United States for management of dyskinesia syndromes, each with a somewhat different spectrum of approved indications: tetrabenazine (Xenazine and generics: 2008), deutetrabenazine (Austedo: 2017) and valbenazine (Ingressa: 2017).

Liver safety of Tetrabenazine

The VMAT2 inihibitors have not been associated with serum enzyme elevations during therapy or linked to instances of clinically apparent liver injury, but they have had limited general clinical use.

Mechanism of action of Tetrabenazine

Tetrabenazine (tet" ra ben' a zeen) is an inhibitor of synaptic vesicular monoamine transporter 2 (VMAT2), the inhibition of which causes a depletion of neuroactive monoamines (serotonin, norepinephrine and particularly dopamine) in nerve terminals. The reduction in these active neurotransmitters results in a decrease in spontaneous jerk-like movements of the extremities, trunk, face and neck (chorea) that are typical of patients with degenerative neurologic conditions such as Huntington disease. Tetrabenazine, however, does not prevent the progression or alter the outcome of these diseases.

FDA approval information for Tetrabenazine

Tetrabenazine was approved by the FDA in 2008 as an orphan disease agent for treatment of the chorea associated with Huntington disease. While it is used off-label to treat other abnormal movement disorders, tetrabenazine is not formally approved for those indications.

Dosage and administration for Tetrabenazine

Tetrabenazine is available as tablets of 12.5 and 25 mg generically and under the brand name Xenazine. The recommended initial dose is 12.5 mg once daily, with subsequent careful increase to a maximum of 50 mg given in three divided doses daily. Because of the variable metabolism of tetrabenazine (by CYP 2D6), the maintenance dose varies by individual, and inducers or inhibitors of CYP 2D6 should be avoided. Poor CYP 2D6 metabolizers may require even higher doses.

Side effects of Tetrabenazine

Common side effects include fatigue, sedation, somnolence, insomnia, depression, restlessness (akathisia), agitation, and nausea. Rare potentially serious adverse events include severe depression, suicidality, symptomatic hypotension, prolongation of the QTc interval and neuroleptic malignant syndrome.

genetic disorder agents

cystic fibrosis agents

enzyme replacement therapy

glucosylceramide synthase inhibitors (substrate restriction therapy)

lysosomal acid lipase deficiency agents

miscellaneous

homocystinuria agents

Huntington disease agents

Monoclonal Antibodies

Tyrosinemia Agents

Urea Cycle Disorder Agents

Hematologic Agents

Cost and Coupons - Tetrabenazine

Reviews for Tetrabenazine


WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Articles on Tetrabenazine

This article is a stub. YOU can help Wikimd by expanding it!

Learn more about Tetrabenazine

Drug classes


WikiMD Resources for Tetrabenazine

Articles

Most recent articles

Most cited

Review articles

Articles on Tetrabenazine in N Eng J Med, Lancet, BMJ

Media Tetrabenazine

Powerpoint slides

Podcasts and MP3's

Videos

Evidence Based Medicine

Cochrane Collaboration

Clinical Trials

Ongoing Trials on Tetrabenazine

Trial results on Tetrabenazine

Clinical Trials on Tetrabenazine at Google

Books and news

Books on Tetrabenazine

Tetrabenazine in the news

Commentary Tetrabenazine

Blogs on Tetrabenazine

Patient Resources / Community

Patient resources

Discussion groups

Patient Handouts

Other resources

Social Media

Reddit
Quora.png
Pins
Instagram
YouTube videos
Flickr
Bing.png

W8MD Weight Loss, Sleep & MedSpa

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U |V | W | X | Y | Z

Ad. Tired of being overweight? W8MD's insurance weight loss program can HELP* | Lose weight King of Prussia, PA | Lose weight NYC | Lose weight NJ | Lose weight Philadelphia Advertise

Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer. * Individual results may vary for weight loss from our sponsors.

Our sponsors WikiMD is supported by W8MD weight loss, sleep and medical aesthetic centers.