Thiamine pyrophosphate
Thiamine Pyrophosphate
Thiamine pyrophosphate (pronounced /ˈθaɪəmiːn paɪroʊˈfɑːsfeɪt/), also known as TPP or thiamine diphosphate, is a coenzyme that is essential for aerobic metabolism.
Etymology
The term "thiamine" comes from the Greek words thio, meaning "sulfur", and amine, a type of organic compound. "Pyrophosphate" refers to a type of phosphate group that is present in the molecule.
Function
Thiamine pyrophosphate plays a crucial role in the metabolism of carbohydrates, fats, and proteins. It acts as a coenzyme for several enzymes involved in the Krebs cycle, including pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase.
Related Terms
- Thiamine: A vitamin, also known as vitamin B1, that is converted into thiamine pyrophosphate in the body.
- Coenzyme: A non-protein compound that is necessary for the functioning of an enzyme.
- Metabolism: The set of life-sustaining chemical reactions in organisms.
- Krebs cycle: A series of chemical reactions used by all aerobic organisms to generate energy.
- Pyruvate dehydrogenase: An enzyme that converts pyruvate into acetyl-CoA, the first step in the Krebs cycle.
- Alpha-ketoglutarate dehydrogenase: An enzyme that plays a key role in the Krebs cycle.
External links
- Medical encyclopedia article on Thiamine pyrophosphate
- Wikipedia's article - Thiamine pyrophosphate
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