Tobramycin

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Information about Tobramycin

tobramycin is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms.

Liver safety of Tobramycin

Despite its wide use, tobramycin has rarely been linked to instances of clinically apparent liver injury.

Mechanism of action of Tobramycin

tobramycin (toe" bra mye' sin) is a semisynthetic aminoglycoside, similar in spectrum of activity to gentamicin, that is widely used for severe bacterial infections caused by sensitive agents, primarily aerobic gram negative bacteria. Like other aminoglycosides, tobramycin is thought to act by binding to bacterial ribosomes and inhibiting protein synthesis. Nevertheless, tobramycin is considered bacteriocidal as well as bacteriostatic. tobramycin and other aminoglycosides are typically used in combination with a penicillin or cephalosporin for treatment of severe infections with E.Coli, Staphylococcus aureus, Enterobacter, Klebsiella, Serratia, Pseudomonas aeruginosa, and other gram negative bacteria resistant to less toxic antibiotics.

Clinical use of Tobramycin

Tobramycin is most commonly used for septicemia, bacterial endocarditis, peritonitis, meningitis, pelvic inflammatory disease and pneumonia.

{fda}} Tobramycin was approved for use in the United States in 1980 and is available in multiple generic forms in parenteral formulations; typical adult doses are 3 mg/kg per day im or iv, usually in three divided doses, often after an initial loading dose. The dose of tobramycin must be modified based upon renal function and monitoring of drug levels is advisable. Pediatric formulations, nebulizer solutions for inhalation, and topical formulations for ophthalmologic use are also available.

Side effects of Tobramycin

Common side effects include dizziness, headache, confusion, nausea and skin rash. Important, dose related adverse effects include oto- and nephrotoxicity, which are shared by all aminoglycosides.

List of aminoglycosides

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