Transient abnormal myelopoiesis

Transient abnormal myelopoiesis
Term	Transient abnormal myelopoiesis
Short definition	Transient abnormal myelopoiesis - (pronounced) (TRAN-zee-ent ab-NOR-mul MY-eh-loh-poy-EE-sis) disease of the bone marrow that can occur in newborn babies with Down syndrome. It is characterized by abnormal, immature haematopoietic cells in the blood and bone marrow (particularly the cells involved in the formation of platelets).
Type	Cancer terms
Specialty	Oncology
Language	English
Source	NCI
Comments

Transient abnormal myelopoiesis - (pronounced) (TRAN-zee-ent ab-NOR-mul MY-eh-loh-poy-EE-sis) disease of the bone marrow that can occur in newborn babies with Down syndrome. It is characterized by abnormal, immature haematopoietic cells in the blood and bone marrow (particularly the cells involved in the formation of platelets). The liver may also be larger than normal. Transient abnormal myelopoiesis is caused by mutations (changes) in a gene called GATA1. The transient abnormal myelopoiesis usually goes away on its own within the first 3 months of life. Sometimes transient abnormal myelopooesis causes serious or life-threatening problems, such as: B. bleeding problems, infections, heart, kidney and liver failure and an abnormal accumulation of fluid in the tissues that cover the organs in the body. Infants with transient abnormal myelopoiesis are at increased risk of developing acute myeloid leukemia (AML) before the age of 3 years. Also called TAM, TMD, transient leukemia and transient myeloproliferative disease

External links

• Medical encyclopedia article on Transient abnormal myelopoiesis
• Wikipedia's article - Transient abnormal myelopoiesis

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