Trichosanthin

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Trichosanthin

Trichosanthin (pronunciation: trik-oh-SAN-thin) is a type of ribosome-inactivating protein derived from the root tubers of Trichosanthes kirilowii, a plant species in the family Cucurbitaceae.

Etymology

The term "Trichosanthin" is derived from the genus name Trichosanthes, which is the plant from which it is extracted, and the suffix "-in", which is commonly used in biochemistry to denote proteins.

Function

Trichosanthin is known for its medicinal properties, particularly its ability to inhibit protein synthesis in cells by depurinating the adenine in the DNA sequence. This property has led to its use in traditional Chinese medicine for the treatment of a variety of conditions, including malignant tumors and viral infections.

Related Terms

  • Ribosome-inactivating protein: A type of protein that inhibits protein synthesis in cells, leading to cell death. Trichosanthin is a type of ribosome-inactivating protein.
  • Trichosanthes kirilowii: The plant species from which trichosanthin is derived.
  • Cucurbitaceae: The plant family to which Trichosanthes kirilowii belongs.
  • Depurination: The removal of a purine base (adenine or guanine) from the DNA sequence, which is a mechanism of action of trichosanthin.
  • Traditional Chinese Medicine: A system of health care that originated in China. Trichosanthin is used in traditional Chinese medicine for its medicinal properties.

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