Umbralisib
Umbralisib
Umbralisib (pronounced um-bra-li-sib) is a pharmacological agent used in the treatment of certain types of cancer. It is classified as a PI3K inhibitor, specifically targeting the delta and gamma isoforms of the enzyme phosphoinositide 3-kinase (PI3K).
Etymology
The name "Umbralisib" is derived from the combination of letters and syllables that pharmaceutical companies use to create a unique name. The exact etymology is not known.
Usage
Umbralisib is used in the treatment of lymphoma, specifically marginal zone lymphoma (MZL) and follicular lymphoma (FL) that has relapsed or is refractory after at least one prior systemic therapy. It works by inhibiting the PI3K pathway, which is often overactive in cancer cells, leading to uncontrolled cell growth and survival.
Related Terms
- Pharmacology: The branch of medicine concerned with the uses, effects, and modes of action of drugs.
- Cancer: A disease caused by an uncontrolled division of abnormal cells in a part of the body.
- PI3K inhibitor: A type of drug that blocks the action of PI3K, a protein that helps control cell growth and division.
- Phosphoinositide 3-kinase (PI3K): An enzyme that in humans is encoded by the PIK3CA gene. It is part of the PI3K/AKT/mTOR pathway, which is a pathway that regulates cell cycle.
- Lymphoma: A type of cancer that begins in infection-fighting cells of the immune system, called lymphocytes.
- Marginal zone lymphoma (MZL): A type of B-cell non-Hodgkin lymphoma.
- Follicular lymphoma (FL): A type of blood cancer. It is the most common of the indolent (slow-growing) non-Hodgkin's lymphomas, and the second-most-common form of non-Hodgkin's lymphomas overall.
External links
- Medical encyclopedia article on Umbralisib
- Wikipedia's article - Umbralisib
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