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valacyclovir (VAL-uh-SY-kloh-veer) is a substance that is being studied in the prevention of fungal, bacterial, and viral infections in patients undergoing donor stem cell transplantation with cells that are infected with cytomegalovirus. It belongs to the family of drugs called antivirals.

Information about Valerian

Valerian is a botanical extract derived from the roots of Valeriana officinalis, which is widely used in herbal medicine for insomnia, anxiety and digestive and urinary problems. 

Liver safety of Valerian

Valerian has been linked to rare instances of clinically apparent liver injury.

Mechanism of action of Valerian

Valerian (va ler' ee an) is the common name of the plant genus Valeriana, several species of which are used in herbal medicine, most typically Valeriana officinalis.  Valerian has been used for centuries in Europe, usually for digestive and urinary problems.  The name valerian derives from the Latin word valere, which means “to be in good health.”  Valerian is claimed to have sedative, hypnotic, anxiolytic, anticonvulsant, antispasmotic and antidepressant activities.  Presently, it is used most commonly as a sleeping aid and for therapy of stress.  The basis for its sedative effects is believed to be valepotriates (which are terpene alcohols) and volatile oils (including monoterpenes and sesquiterpenes).  Components of valerian are believed to interact with the gamma amino butyric acid (GABA) receptor in a manner similar to the benzodiazepines.  The typical dosage of valerian is 300 to 600 mg at bedtime for sleep or taken 3 times daily for stress.  Valerian is found in many relaxation drinks.  Valerian has few side effects, which are mostly mild and transient and include sedation, dizziness and withdrawal symptoms on stopping.

Herbal and dietary supplements

Chinese and Other Asian Herbal Medicines

Multi-Ingredient Nutritional Supplements

See also Nutritional supplements

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