Vinorelbine
Vinorelbine (vih-NOR-el-been) is the active ingredient in a drug used alone or with cisplatin to treat non-small cell lung cancer that is locally advanced or has spread to other parts of the body. It is also being studied in the treatment of other types of cancer.
Mechanism of action of Vinorelbine
Vinorelbine blocks cell growth by stopping cell division and may cause cancer cells to die. It is a type of vinca alkaloid and a type of antimitotic agent.
Information about Vinorelbine
The vinca alkaloids include vincristine, vinblastine and vinorelbine which are important antineoplastic agents used in many chemotherapeutic regimens for a wide variety of cancers.
Liver safety of Vinorelbine
Despite their cytotoxic activity against cancer cells, the vinca alkaloids have rarely been implicated in causing clinically apparent acute liver injury.
Mechanism of action of Vinorelbine
The vinca alkaloids are antineoplastic agents that act by binding to intracellular tubulin, the basic protein subunit of microtubules which are important in many intracellular processes including mitosis and cell division. The vinca alkaloids inhibit cell division by blocking mitosis; they also inhibit purine and RNA synthesis causing death of rapidly dividing cells. Vincristine and vinblastine were initially isolated from periwinkle (vinca rosea), extracts of which were found to have antitumor activity. Subsequently, they have been synthesized, although their structure is quite complex. Vinorelbine is a semisynthetic derivative of extracts of periwinkle. Vincristine (vin kris' teen) was approved for use in cancer chemotherapy in 1963, vinblastine (vin blas' teen) in 1965 and vinrelbine (vin or' el been) in 1994. They have become major components of many combination anticancer regimens, used particularly in treatment of acute leukemia, Hodgkin disease and other lymphomas, various sarcomas, Wilms tumor, neuroblastoma, and breast and lung cancer.
Brand name for Vinorelbine
The vinca alkaloids are given intravenously, typically at one or two week intervals in cycles with other agents. The vinca alkaloids are available in generic forms and under the trade names Oncovin (vincristine), Velban (vinblastine) and Navelbine (Vinorelbine). side effects are common and include nausea, vomiting, fatigue, headache, dizziness, peripheral neuropathy, hoarseness, ataxia, dysphagia, urinary retention, constipation, diarrhea, bone marrow suppression, alopecia and phlebitis at the infusion site.
The article on Vinorelbine is a stub. YOU can help Wikimd by expanding it!
Medication resources
Learn more
About WikiMD
About us: WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.
Our mission: Provide up to date physician reviewed health, nutrition and wellness information for free in over 100 languages.
Join us: This article is a stub. Help improve Vinorelbine or others. Do not trust amateurs with your life! Join us in this effort!. Paid editors welcome.
 Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP* |
Quick links: Medicine Portal | Encyclopedia | Gray's Anatomy | Topics | Diseases | Drugs | Wellness | Obesity | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="http://www.wikimd.org/wiki/Vinorelbine">Vinorelbine</a>
- Individual results may vary for weight loss from our sponsors.