WikiMD is the world's largest medical encyclopedia with
14,007 pages, 4,159,086 edits & 43,392,504 views.
Vinorelbine
Vinorelbine (vih-NOR-el-been) is the active ingredient in a drug used alone or with cisplatin to treat non-small cell lung cancer that is locally advanced or has spread to other parts of the body. It is also being studied in the treatment of other types of cancer.
Mechanism of action of Vinorelbine
Vinorelbine blocks cell growth by stopping cell division and may cause cancer cells to die. It is a type of vinca alkaloid and a type of antimitotic agent.
Information about Vinorelbine
The vinca alkaloids include vincristine, vinblastine and vinorelbine which are important antineoplastic agents used in many chemotherapeutic regimens for a wide variety of cancers.
Liver safety of Vinorelbine
Despite their cytotoxic activity against cancer cells, the vinca alkaloids have rarely been implicated in causing clinically apparent acute liver injury.
Mechanism of action of Vinorelbine
The vinca alkaloids are antineoplastic agents that act by binding to intracellular tubulin, the basic protein subunit of microtubules which are important in many intracellular processes including mitosis and cell division. The vinca alkaloids inhibit cell division by blocking mitosis; they also inhibit purine and RNA synthesis causing death of rapidly dividing cells. Vincristine and vinblastine were initially isolated from periwinkle (vinca rosea), extracts of which were found to have antitumor activity. Subsequently, they have been synthesized, although their structure is quite complex. Vinorelbine is a semisynthetic derivative of extracts of periwinkle. Vincristine (vin kris' teen) was approved for use in cancer chemotherapy in 1963, vinblastine (vin blas' teen) in 1965 and vinrelbine (vin or' el been) in 1994. They have become major components of many combination anticancer regimens, used particularly in treatment of acute leukemia, Hodgkin disease and other lymphomas, various sarcomas, Wilms tumor, neuroblastoma, and breast and lung cancer.
Brand name for Vinorelbine
The vinca alkaloids are given intravenously, typically at one or two week intervals in cycles with other agents. The vinca alkaloids are available in generic forms and under the trade names Oncovin (vincristine), Velban (vinblastine) and Navelbine (Vinorelbine). side effects are common and include nausea, vomiting, fatigue, headache, dizziness, peripheral neuropathy, hoarseness, ataxia, dysphagia, urinary retention, constipation, diarrhea, bone marrow suppression, alopecia and phlebitis at the infusion site.
Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ
Cost and Coupons - Vinorelbine
- GoodRx compare cost & coupons for Vinorelbine
- Find the lowest cost of Vinorelbine
- Search for Coupons for Vinorelbine
Reviews for Vinorelbine
Learn more about Vinorelbine
- Dailymed label info
- Scientific articles
- Drug portal Vinorelbine
- toxicity info on Vinorelbine
- FDA Vinorelbine
Latest research - Vinorelbine
External links
This WikiMD article Vinorelbine is a stub. If you are familiar with the topic Vinorelbine, you can help us. Paid editors welcome!
Vinorelbine is part of WikiMD's free ^articles!
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
 Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available |
