Voclosporin

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Voclosporin

Voclosporin (pronounced voe-kloe-spor-in) is a novel immunosuppressant drug that is structurally similar to cyclosporine A, but with modifications that enhance its potency and metabolic stability. It is used in the treatment of lupus nephritis, a kidney disorder associated with systemic lupus erythematosus.

Etymology

The name "Voclosporin" is derived from the Latin words voclo, meaning voice, and sporin, referring to its spore-like structure. The name signifies the drug's ability to "speak" to the immune system and control its response.

Pharmacology

Voclosporin works by inhibiting the enzyme calcineurin, which plays a crucial role in the activation of T-cells, a type of white blood cell that plays a key role in the body's immune response. By inhibiting calcineurin, Voclosporin prevents the activation of T-cells, thereby suppressing the immune response.

Related Terms

  • Immunosuppressant: A type of drug that reduces the body's immune response, used to prevent rejection of transplanted organs and to treat autoimmune diseases.
  • Cyclosporine A: A powerful immunosuppressant drug that is structurally similar to Voclosporin.
  • Lupus nephritis: A serious complication of systemic lupus erythematosus, in which the kidneys become inflamed.
  • Systemic lupus erythematosus: A chronic autoimmune disease in which the body's immune system attacks its own tissues and organs.
  • Calcineurin: An enzyme that plays a crucial role in the activation of T-cells.
  • T-cells: A type of white blood cell that plays a key role in the body's immune response.

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