WS

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WS
TermWS
Short definitionWS - A rare, inherited disorder characterized by rapid aging beginning in early adolescence or young adulthood and associated with an increased risk of cancer. Signs and symptoms include being shorter than average, thinning and graying hair, skin changes, thin arms and legs, voice changes, and unusual facial features. 
TypeCancer terms
SpecialtyOncology
LanguageEnglish
SourceNCI
Comments


WS - A rare, inherited disorder characterized by rapid aging beginning in early adolescence or young adulthood and associated with an increased risk of cancer. Signs and symptoms include being shorter than average, thinning and graying hair, skin changes, thin arms and legs, voice changes, and unusual facial features. This disorder can also lead to health problems such as cataracts, skin ulcers, severe hardening of the arteries, diabetes, osteoporosis and fertility problems. People with WS have an increased risk of cancer, particularly thyroid cancer, skin cancer, and sarcoma (a type of bone or soft tissue cancer). WS is caused by a mutation (change) in the WRN gene, which produces a protein involved in DNA repair. Also called adult progeria and Werner syndrome

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