Warfarin resistance
Warfarin Resistance
Warfarin resistance is a medical condition where the body's response to the anticoagulant drug Warfarin is reduced, leading to a decreased effectiveness of the drug.
Pronunciation
Warfarin resistance: /wɔːrfərɪn rɪˈzɪstəns/
Etymology
The term "Warfarin" is derived from the acronym WARF, for the Wisconsin Alumni Research Foundation + the ending -arin indicating its link with coumarin, the chemical compound it is derived from. "Resistance" comes from the Latin resistere, meaning "to withstand".
Definition
Warfarin resistance can be defined as a decreased susceptibility to the effects of the anticoagulant drug Warfarin. This can be due to genetic factors, dietary habits, or interactions with other drugs.
Symptoms
Symptoms of Warfarin resistance may not be immediately apparent, as they are often similar to the conditions for which Warfarin is prescribed. These can include increased clotting, deep vein thrombosis, and pulmonary embolism.
Causes
Warfarin resistance can be caused by a variety of factors. Genetic mutations in the VKORC1 gene, which is responsible for the production of Vitamin K epoxide reductase, the enzyme Warfarin targets, can lead to resistance. Additionally, dietary habits such as high Vitamin K intake can reduce the effectiveness of Warfarin. Interactions with other drugs can also lead to Warfarin resistance.
Treatment
Treatment for Warfarin resistance often involves adjusting the dosage of Warfarin or switching to a different anticoagulant drug. Genetic testing may be used to determine the cause of the resistance and guide treatment decisions.
Related Terms
External links
- Medical encyclopedia article on Warfarin resistance
- Wikipedia's article - Warfarin resistance
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