X-linked recessive
X-linked recessive
X-linked recessive is a mode of genetic inheritance by which a mutation in a gene on the X chromosome causes the phenotype to be expressed in males (who are necessarily homozygous for the gene mutation because they have one X and one Y chromosome) and in females who are homozygous for the gene mutation (i.e., they have a copy of the gene mutation on each of their two X chromosomes).
Pronunciation
- X-linked: /ˈɛksˌlɪŋkt/
- recessive: /rɪˈsɛsɪv/
Etymology
The term "X-linked" refers to the X chromosome, one of the two sex chromosomes in humans, and "recessive" refers to the type of genetic inheritance where two copies of a gene are necessary to express a trait.
Related Terms
- Genetic inheritance: The process by which genetic information is passed on from parent to child. This is the basis for traits such as skin color, eye color and hair color.
- Homozygous: Having two identical alleles of a particular gene or genes.
- Sex chromosomes: A type of chromosome in the genome that is involved in determining the sex of an organism, typically one of two kinds.
- Gene mutation: A permanent alteration in the DNA sequence that makes up a gene.
External links
- Medical encyclopedia article on X-linked recessive
- Wikipedia's article - X-linked recessive
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