Ziconotide
Ziconotide (pronounced as zi-koh-noh-tide) is a non-opioid analgesic used for the management of severe chronic pain. It is derived from the venom of the marine cone snail species Conus magus.
Pronunciation
The term 'Ziconotide' is pronounced as "zi-koh-noh-tide".
Etymology
The name 'Ziconotide' is derived from the Conus magus, a species of cone snail that produces the venom from which the drug is synthesized. The 'Zico' part of the name is a reference to the genus Zicon, which is a subgenus of Conus. The '-tide' suffix is commonly used in pharmacology to denote peptides, which are the primary constituents of the drug.
Pharmacology
Ziconotide works by blocking N-type voltage-sensitive calcium channels, which are located in the brain and spinal cord. This action prevents the release of pain signals from the peripheral nerves to the brain. Unlike opioids, ziconotide does not have any known risk of addiction or tolerance.
Usage
Ziconotide is used for the management of severe chronic pain that cannot be controlled by other pain medications. It is administered intrathecally, or directly into the spinal fluid, using a surgically implanted pump.
Side Effects
Common side effects of ziconotide include dizziness, nausea, confusion, and headache. Severe side effects may include hallucinations, severe psychiatric symptoms, and kidney problems.
Related Terms
External links
- Medical encyclopedia article on Ziconotide
- Wikipedia's article - Ziconotide
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