Zuranolone
Zuranolone
Zuranolone (pronounced: zuh-ran-oh-lone) is a neuroactive steroid and positive allosteric modulator of the gamma-aminobutyric acid type A receptor (GABAA receptor). It is under development for the treatment of major depressive disorder and postpartum depression.
Etymology
The name "Zuranolone" is derived from the chemical structure of the compound. The prefix "Zura-" is a modification of "pyrazole", a component of the chemical structure, and "-nolone" is a common suffix used in the names of steroids, indicating the presence of a ketone group.
Pharmacology
Zuranolone acts as a positive allosteric modulator of the GABAA receptor, the major inhibitory neurotransmitter receptor in the brain. By enhancing the activity of this receptor, Zuranolone can increase the inhibitory effects of GABA, potentially reducing the symptoms of depression.
Clinical Trials
Zuranolone has undergone several clinical trials for the treatment of major depressive disorder and postpartum depression. The results of these trials have shown promise, but further research is needed to confirm the efficacy and safety of this drug.
Related Terms
- Neuroactive steroid
- Positive allosteric modulator
- Gamma-aminobutyric acid
- Major depressive disorder
- Postpartum depression
- Clinical trial
External links
- Medical encyclopedia article on Zuranolone
- Wikipedia's article - Zuranolone
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