Validol

Validolum (Валидол® Validol ®) is a menthyl ester of isovaleric acid. It is a transparent oily, colorless liquid with a smell of menthol. It is very slightly soluble in alcohol, while practically insoluble in water.

Sublingual administration purportedly produces a sedative effect, and has moderate reflex and vascular dilative action caused by stimulation of sensory nerve receptors of the oral mucosa followed by the release of endorphins.

Sublingual Validolum is prescribed for neurocirculatory dystonia (NCD), angina pectoris, cardiac chest pain, neuroses, hysteria, panic attacks, anxiety (anxiolytic) and nausea (as an antiemetic). A 10 percent alcohol solution of Validolum is prescribed to relieve itchy skin.

It is generally safe to use with few to none side effects. There is no known LD50.