MLL (gene)

Histone-lysine N-methyltransferase HRX is an enzyme that in humans is encoded by the MLL (ALL1) gene. MLL stands for Myeloid/Lymphoid, or Mixed-Lineage, Leukemia.

MLL is a histone methyltransferase deemed a positive global regulator of gene transcription. This protein belongs to the group of histone-modifying enzymes comprising transactivation domain 9aaTAD; ; ; ; ; and is involved in the epigenetic maintenance of transcriptional memory.

Rearrangements of the MLL gene are associated with aggressive acute leukemias, both lymphoblastic and myeloid. It also may participate in the process of GAD67 downregulation in schizophrenia.

Interactions
MLL (gene) has been shown to interact with HDAC1, PPP1R15A, Host cell factor C1, MEN1, RBBP5, ASH2L, CREB binding protein, WDR5, CTBP1 and PPIE.