Sorivudine

Sorivudine (INN) chemical name (E)-5-(2-Bromovinyl)- 1β-D-arabinofuranosyluracil, is a thymine analogue antiviral drug, marketed under trade names such as Usevir (Nippon Shoji, Eisai) and Brovavir (BMS).

Feature

 * First-line treatment of herpes drug acyclovir was (Zovirax, Activir) from VZV strong activity of the virus.
 * Superior gastrointestinal absorption, absorption from the gastrointestinal tract after the most degrading without being excreted as urine.

Mechanism of action

 * Sorivudine is phosphorylated by thymidine kinase activity in the body and is absorbed into the virus's DNA instead of the correct nucleoside. It is a competitive inhibitor of DNA polymerase, so the viral DNA cannot be replicated and the virus cannot grow.

Microbiology
Sorivudine is active against most species in the herpesvirus family.
 * Herpes simplex virus type I (HSV-1)
 * Varicella zoster virus (VZV)
 * Epstein-Barr virus (EBV)