Leucoerythroblastic

A leukoerythroblastic (or leucoerythroblastic) picture on blood film can be the bone marrow response to any irritation including marrow infiltration [causing immature red cells]. Marrow infiltrative disorders include myelomas, malignancy, myelofibrosis, Gaucher’s disease etc. It can also occur as a response to severe critical illness, such as trauma, septicaemia, massive haemolysis, or severe megaloblastic anaemia. Leukoerthyroblastic change refers to the presence of nucleated red blood cells and primitive white blood cells.

Seen in bone marrow failure, myelofibrosis and extramedullary haemopoiesis.

Features of leucoerythrobloastic anaemia include:
 * normocytic normochromic anaemia with numerous poikilocytes
 * normoblasts (nucleated red cells)
 * low-grade reticulocytosis (2-5%)
 * circulating immature white cells, generally myelocytes and promyelocytes
 * thrombocytopaenia is more common than thrombocythaemia