Umbilical cord

In placental mammals, the umbilical cord (also called the navel string, birth cord or funiculus umbilicalis) is a conduit between the developing embryo or fetus and the placenta. During prenatal development, the umbilical cord is physiologically and genetically part of the fetus and (in humans) normally contains two arteries (the umbilical arteries) and one vein (the umbilical vein), buried within Wharton's jelly. The umbilical vein supplies the fetus with oxygenated, nutrient-rich blood from the placenta. Conversely, the fetal heart pumps deoxygenated, nutrient-depleted blood through the umbilical arteries back to the placenta.

Development and composition
The umbilical cord develops from and contains remnants of the yolk sac and allantois (and is therefore derived from the zygote). It forms by the fifth week of fetal development, replacing the yolk sac as the source of nutrients for the fetus. The cord is not directly connected to the mother's circulatory system, but instead joins the placenta, which transfers materials to and from the mother's blood without allowing direct mixing. The length of the umbilical cord is approximately equal to the crown-rump length of the fetus throughout pregnancy. The umbilical cord in a full term neonate is usually about 50 centimeters (20 in) long and about 2 centimeters (0.75 in) in diameter. This diameter decreases rapidly within the placenta. The fully patent umbilical artery has two main layers: an outer layer consisting of circularly arranged smooth muscle cells and an inner layer which shows rather irregularly and loosely arranged cells embedded in abundant ground substance staining metachromatic. The smooth muscle cells of the layer are rather poorly differentiated, contain only a few tiny myofilaments and are thereby unlikely to contribute actively to the process of postnatal closure.

The umbilical cord contains Wharton's jelly, a gelatinous substance made largely from mucopolysaccharides which protects the blood vessels inside. It contains one vein, which carries oxygenated, nutrient-rich blood to the fetus, and two arteries that carry deoxygenated, nutrient-depleted blood away. Occasionally, only two vessels (one vein and one artery) are present in the umbilical cord. This is sometimes related to fetal abnormalities, but it may also occur without accompanying problems.

It is unusual for a vein to carry oxygenated blood and for arteries to carry deoxygenated blood (the only other examples being the pulmonary veins and arteries, connecting the lungs to the heart). However, this naming convention reflects the fact that the umbilical vein carries blood towards the fetus's heart, while the umbilical arteries carry blood away.

The blood flow through the umbilical cord is approximately 35 ml / min at 20 weeks, and 240 ml / min at 40 weeks of gestation. Adapted to the weight of the fetus, this corresponds to 115 ml / min / kg at 20 weeks and 64 ml / min / kg at 40 weeks.

Connection to fetal circulatory system
The umbilical cord enters the fetus via the abdomen, at the point which (after separation) will become the umbilicus (or navel). Within the fetus, the umbilical vein continues towards the transverse fissure of the liver, where it splits into two. One of these branches joins with the hepatic portal vein (connecting to its left branch), which carries blood into the liver. The second branch (known as the ductus venosus) bypasses the liver and flows into the inferior vena cava, which carries blood towards the heart. The two umbilical arteries branch from the internal iliac arteries, and pass on either side of the urinary bladder into the umbilical cord, completing the circuit back to the placenta.

Physiological postnatal occlusion
In absence of external interventions, the umbilical cord occludes physiologically shortly after birth, explained both by a swelling and collapse of Wharton's jelly in response to a reduction in temperature and by vasoconstriction of the blood vessels by smooth muscle contraction. In effect, a natural clamp is created, halting the flow of blood. In air at 18°C, this physiological clamping will take three minutes or less. In water birth, where the water temperature is close to body temperature, normal pulsation can be 5 minutes and longer.

Closure of the umbilical artery by vasoconstriction consists of multiple constrictions which increase in number and degree with time. There are segments of dilatations with trapped uncoagulated blood between the constrictions before complete occlusion. Both the partial constrictions and the ultimate closure are mainly produced by muscle cells of the outer circular layer. In contrast, the inner layer seems to serve mainly as a plastic tissue which can easily be shifted in an axial direction and then folded into the narrowing lumen to complete the closure. The vasoconstrictive occlusion appears to be mainly mediated by 5-hydroxytryptamine and thromboxane A2. The artery in cords of preterm infants contracts more to angiotensin II and arachidonic acid and is more sensitive to oxytocin than in term ones. In contrast to the contribution of Wharton's jelly, cooling causes only temporary vasoconstriction.

Within the child, the umbilical vein and ductus venosus close up, and degenerate into fibrous remnants known as the round ligament of the liver and the ligamentum venosum respectively. Part of each umbilical artery closes up (degenerating into what are known as the medial umbilical ligaments), while the remaining sections are retained as part of the circulatory system.

Problems and abnormalities
A number of abnormalities can affect the umbilical cord, which can cause problems that affect both mother and child:
 * Umbilical cord compression can result from, for example, entanglement of the cord, a knot in the cord, or a nuchal cord, (which is the wrapping of the umbilical cord around the fetal neck) but these conditions do not always cause obstruction of fetal circulation.
 * Velamentous cord insertion
 * Single umbilical artery
 * Umbilical cord prolapse
 * Vasa praevia

Clamping and cutting


The cord can be clamped at different times; however delaying the clamping of the umbilical cord until one minute after birth improves outcomes as long as there is the ability to treat jaundice if it occurs. Clamping is followed by cutting of the cord, which is painless due to the absence of nerves. The cord is extremely tough, like thick sinew, and so cutting it requires a suitably sharp instrument. While umbilical severance may be delayed until after the cord has stopped pulsing (5–20 minutes after birth), there is ordinarily no significant loss of either venous or arterial blood while cutting the cord. Current evidence neither supports, nor refutes, delayed cutting of the cord, according to American College of Obstetricians & Gynecologists (ACOG) guidelines.

There are umbilical cord clamps which combine the cord clamps with the knife. These clamps are safer and faster, allowing one to first apply the cord clamp and then cut the umbilical cord. After the cord is clamped and cut, the newborn wears a plastic clip on the navel area until the compressed region of the cord has dried and sealed sufficiently.

The length of umbilical left attached to the newborn varies by practice; in most hospital settings the length of cord left attached after clamping and cutting is minimal. In some counties in the United States, however, where the birth occurred outside of the hospital and an emergency medical technician (EMT) clamps and cuts the cord, a longer segment up to 7 inches in length is left attached to the newborn.

The remaining umbilical stub remains for up to 10 days as it dries and then falls off.

Early versus delayed clamping
A Cochrane review in 2013 came to the conclusion that delayed cord clamping (between one and three minutes after birth) is "likely to be beneficial as long as access to treatment for jaundice requiring phototherapy is available". In this review delayed clamping, as contrasted to early, resulted in no difference in risk of severe maternal postpartum hemorrhage or neonatal mortality, low Apgar score. On the other hand, delayed clamping resulted in an increased birth weight of on average about 100 g, and an increased hemoglobin concentration of on average 1.5 g/dL with half the risk of being iron deficient at three and six months, but an increased risk of jaundice requiring phototherapy.

In 2012, the American College of Obstetricians and Gynecologists officially endorsed delaying clamping of the umbilical cord for 30–60 seconds with the newborn held below the level of the placenta in all cases of preterm delivery based largely on evidence that it reduces the risk of intraventricular hemorrhage in these children by 50%. In the same committee statement, ACOG also recognize several other likely benefits for preterm infants, including "improved transitional circulation, better establishment of red blood cell volume, and decreased need for blood transfusion", as well as several for full term infants, including improved iron stores and increased blood volume, however it stopped short of endorsing delayed clamping for term infants due to a lack of evidence showing that these improved final outcomes or outweighed the increased risk of polycythemia or hyperbilirubinemia associated with delayed clamping.

Several studies have shown benefits of delayed cord clamping: A meta-analysis showed that delaying clamping of the umbilical cord in full-term neonates for a minimum of 2 minutes following birth is beneficial to the newborn in giving improved hematocrit, iron status as measured by ferritin concentration and stored iron, as well as a reduction in the risk of anemia (relative risk, 0.53; 95% CI, 0.40-0.70). A decrease was also found in a study from 2008. Although there is higher hemoglobin level at 2 months, this effect did not persist beyond 6 months of age.

Negative effects of delayed cord clamping include an increased risk of polycythemia. Still, this condition appeared to be benign in studies. Infants whose cord clamping occurred later than 60 seconds after birth had a higher rate of neonatal jaundice requiring phototherapy.

Delayed clamping is not recommended as a response to cases where the newborn is not breathing well and needs resuscitation. Rather, the recommendation is instead to immediately clamp and cut the cord and perform cardiopulmonary resuscitation. The umbilical cord pulsating is not a guarantee that the baby is receiving enough oxygen.

Umbilical nonseverance
Some parents choose to omit cord severance entirely, a practice called "lotus birth" or umbilical nonseverance. The entire intact umbilical cord is allowed to dry and separates on its own (typically on the 3rd day after birth), falling off and leaving a healed umbilicus.

Umbilical cord catheterization
As the umbilical vein is directly connected to the central circulation, it can be used as a route for placement of a venous catheter for infusion and medication. The umbilical vein catheter is a reliable alternative to percutaneous peripheral or central venous catheters or intraosseous canulas and may be employed in resuscitation or intensive care of the newborn.

Storage of cord blood
The blood within the umbilical cord, known as cord blood, is a rich and readily available source of primitive, undifferentiated stem cells (of type CD34-positive and CD38-negative). These cord blood cells can be used for bone marrow transplant.

Some parents choose to have this blood diverted from the baby's umbilical blood transfer through early cord clamping and cutting, to freeze for long-term storage at a cord blood bank should the child ever require the cord blood stem cells (for example, to replace bone marrow destroyed when treating leukemia). This practice is controversial, with critics asserting that early cord blood withdrawal at the time of birth actually increases the likelihood of childhood disease, due to the high volume of blood taken (an average of 108ml) in relation to the baby's total supply (typically 300ml). The Royal College of Obstetricians and Gynaecologists stated in 2006 that "there is still insufficient evidence to recommend directed commercial cord blood collection and stem-cell storage in low-risk families".

The American Academy of Pediatrics has stated that cord blood banking for self-use should be discouraged (as most conditions requiring the use of stem cells will already exist in the cord blood), while banking for general use should be encouraged. In the future, cord blood-derived embryonic-like stem cells (CBEs) may be banked and matched with other patients, much like blood and transplanted tissues. The use of CBEs could potentially eliminate the ethical difficulties associated with embryonic stem cells (ESCs).

While the American Academy of Pediatrics discourages private banking except in the case of existing medical need, it also says that information about the potential benefits and limitations of cord blood banking and transplantation should be provided so that parents can make an informed decision.

In the United States, cord blood education has been supported by legislators at the federal and state levels. In 2005, the National Academy of Sciences published an Institute of Medicine (IoM) report which recommended that expectant parents be given a balanced perspective on their options for cord blood banking. In response to their constituents, state legislators across the country are introducing legislation intended to help inform physicians and expectant parents on the options for donating, discarding or banking lifesaving newborn stem cells. Currently 17 states, representing two-thirds of U.S. births, have enacted legislation recommended by the IoM guidelines.

The use of cord blood stem cells in treating conditions such as brain injury and Type 1 Diabetes is already being studied in humans, and earlier stage research is being conducted for treatments of stroke, and hearing loss.

Cord blood stored with private banks is typically reserved for use of the donor child only. In contrast, cord blood stored in public banks is accessible to anyone with a closely matching tissue type and demonstrated need. The use of cord blood from public banks is increasing. Currently it is used in place of a bone marrow transplant in the treatment of blood disorders such as leukemia, with donations released for transplant through one registry, Netcord.org, passing 1,000,000 as of January 2013. Cord blood is used when the patient cannot find a matching bone marrow donor; this "extension" of the donor pool has driven the expansion of public banks.

Anatomy
The umbilical cord in some mammals contains two distinct umbilical veins, rather than just one (as is the case for humans). Examples include cows and sheep.

Cord disposal
In some animals, the mother will gnaw through the cord, thus separating the placenta from the offspring. It (along with the placenta) is often eaten by the mother, to provide nourishment and to dispose of tissues that would otherwise attract scavengers or predators. In chimpanzees, the mother focuses no attention on umbilical severance, instead nursing her baby with cord, placenta, and all, until the cord dries and separates within a day of birth, at which time the cord is discarded. (This was first documented by zoologists in the wild in 1974. )

Other uses for the term "umbilical cord"
The term "umbilical cord" or just "umbilical" has also come to be used for other cords with similar functions, such as the hose connecting surface-supplied divers to their surface supply of air and/or heating, or space-suited astronauts to their spacecraft. Engineers sometimes use the term to describe a complex or critical cable connecting a component, especially when composed of bundles of conductors of different colors, thickness and types, terminating in a single multi-contact disconnect.

Cancer-causing toxins in human umbilical cords
In multiple American and international studies, cancer-causing chemicals have been found in the blood of umbilical cords. These originate from certain plastics, computer circuit boards, fumes and synthetic fragrances among others. Over 300 toxic chemicals have been found, including Bisphenol A (BPA), tetrabromobisphenol A (TBBPA), Teflon-relative perfluorobutanoic acid, galaxolide and tonalide among others. Blacks, Hispanics and Asians; and the poor tend to have higher rates.