5-Ethoxy-DMT

5-Ethoxy-N,N-dimethyltryptamine (5-EtO-DMT, O-Ethylbufotenine) is a tryptamine derivative, which has been previously synthesised as a chemical intermediate, but has not been studied to determine its pharmacology. Some closely related compounds have been studied and found to act as agonists at the 5-HT1A and 5-HT1D serotonin receptors, with increasing selectivity for 5-HT1D as the 5-alkoxy chain is lengthened, but generally reduced affinity with N,N-dialkylation. The affinity of larger 5-position substituted N,N-dialkyltryptamines at the 5-HT2 receptor subtypes has in most cases not been studied, but the widespread recreational use of N,N-dialkylated 5-methoxytryptamine derivatives including 5-MeO-DMT, 5-MeO-MiPT and 5-MeO-DiPT has led to concern that the 5-ethoxy homologues of these drugs could emerge as novel designer drugs, and consequently not only 5-EtO-DMT but also other derivatives including 5-EtO-DET, 5-EtO-DPT, 5-EtO-DiPT, 5-EtO-DALT, 5-EtO-MPT, 5-EtO-MiPT, 5-EtO-EiPT, 5-EtO-MET and 5-EtO-EPT, were synthesised as analytical standards in order to facilitate future research into these compounds.