Conessine

Conessine is a steroid alkaloid found in a number of plant species from the Apocynaceae family, including Holarrhena floribunda, Holarrhena antidysenterica and Funtumia elastica, several of which are used in traditional herbal medicine as a treatment for amoebic dysentery. It acts as a histamine antagonist, selective for the H3 subtype (with an affinity of pKi=8.27; Ki~5nM). It was also found to have long CNS clearance times, high blood-brain barrier penetration and high affinity for the adrenergic receptors.