PK/PD models

PK/PD (Pharmacokinetic/Pharmacodynamic) modeling (alternatively abbreviated as PKPD or PK-PD modeling) is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics. It integrates a pharmacokinetic and a pharmacodynamic model component into one set of mathematical expressions that allows the description of the time course of effect intensity in response to administration of a drug dose.

There are a variety of PK/PD modeling approaches, but there are only five major classes:
 * Direct link PK/PD models
 * Indirect link PK/PD models
 * Indirect response PK/PD models
 * Cell Lifespan models
 * Complex response models