LY-379,268

LY-379,268 is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (mGluR2/3).

It is derived from the older mGluR group II agonist eglumegad, and led on to the development of the more potent compound LY-404,039, but is still widely used in research itself. LY-379,268 has sedative, neuroprotective, anti-addictive and anticonvulsant effects in animals,  and blocks the effects of PCP and DOI,    which has led to research into LY-379,268 and similar compounds as antipsychotic drugs for the treatment of schizophrenia.

There are inconsistent findings about an additional activity as a dopamine D2 receptor partial agonist.