Proteomic Code

The Proteomic Code is a set of rules by which information in genetic material is transferred into the physicochemical properties of amino acids and determines how individual amino acids interact with each other during folding and in specific protein–protein interactions. The Proteomic Code is part of the redundant Genetic Code. The 25 years old history of this concept is reviewed from the first suggestion in 1981 by Mekler and Biro through the hypothesis of a Common Periodic Table of Codons and Nucleic acids in 2003 and the recent conceptualization of partial complementary coding of interacting amino acids as well as the theory of the nucleic acid assisted protein folding.

However, the idea of complementary coding as source for protein–protein interactions, which forms the basis for the Proteomic Code Hypothesis, has been shown to be false, as no compelling evidence yet exists that antisense-like domains play any role in the folding or conformation of proteins.