Dopamine antagonist

A dopamine antagonist is a drug which blocks dopamine receptors (of which there are five types in the human body; they are found in the brain, peripheral nervous system, blood vessels, and the kidney).

Some of these drugs are commonly coupled with a serotonin antagonist and are used as a treatment for certain kinds of psychosis. Dopamine antagonists used in psychiatry for psychosis include the atypical antipsychotics clozapine, risperidone, olanzapine, quetiapine, ziprasidone and aripiprazole.

Other dopamine antagonists include the antiemetics metoclopramide, droperidol, domperidone and the tricyclic antidepressant amoxapine.