Ecogenetics diseases

Ecogenetics is the branch of genetics that studies how (inherited or acquired) genetic factors influence human susceptibility to environmental health risks. It studies the genetic basis of environmental toxicity to develop methods for the detection, prevention and control of environmentally-related disease. Ecogenetics interacts with ecology, molecular genetics, toxicology, public health medicine, and environmental epidemiology.

Ecogenetic diseases: An intermediate bw monogenic and poly genic- because they are relatively rare (as monogenic) but have very strong environmental influence as polygenic.

Malignant Hyperthermia

 * An autosomal dominant disease, a mutation in rayamodine receptor in the sarcoplasmic er.
 * Features: High fever which is induce by anastatics as: halothane, succinylchline.

G6PD deficiency - favism

 * An x linked recessive disorder affecting mainly men, but can affect women due to X inactivation
 * Features: hemolytic shock, Naphthalene balls, broad bean.

Acute intermidated porpliria

 * Autosomal dominant
 * Symptoms: periods interrupted by acute symptomes periods
 * Triggers: alcohol, steroid, infection