Fourth heart sound



The fourth heart sound or S4 is a rare extra heart sound that occurs immediately before the normal two "lub-dub" heart sounds (S1 and S2). It occurs just after atrial contraction and immediately before the systolic S1 and is caused by the atria contracting forcefully in an effort to overcome an abnormally stiff or hypertrophic ventricle.

This produces a rhythm classically compared to the cadence of the word "Tennessee" with the first syllable ("Ten-") representing S4. One can also use the phrase "a-STIFF-wall" to help with the cadence (a S4, stiff S1, wall S2), as well as the pathology of the S4 sound.

Physiology
The normal heart sounds, S1 and S2, are produced by closing of the atrioventricular valves and semilunar valves, respectively. The closing of these valves produces a brief period of turbulent flow, which produces sound.

The S4 sound occurs, by definition, immediately before S1, while the atria of the heart are vigorously contracting. It is manifest as a vibration of 20 to 30 Hz within the ventricle. While the mechanism is not absolutely certain, it is generally accepted that S4 is caused by stiffening of the walls of the ventricles (usually the left), which produces abnormally turbulent flow as the atria contract to force blood into the ventricle.

S4 is sometimes audible in the elderly due to a more rigid ventricle. When loud, it is a sign of a pathologic state, usually a failing left ventricle. If the problem lies with the left ventricle, the gallop rhythm will be heard best at the cardiac apex. It will become more apparent with exercise, with the patient lying on their left-hand side, or with the patient holding expiration. If the culprit is the right ventricle, the abnormal sound will be most evident on the lower left hand side of the sternum and will get louder with exercise and quick, deep inspiration.

S4 has also been termed an atrial gallop or a presystolic gallop because of its occurrence late in the heart cycle. It is a type of gallop rhythm by virtue of having an extra sound; the other gallop rhythm is called S3. The two are quite different, but they may sometimes occur together forming a quadruple gallop. If the heart rate is also very fast (tachycardia), it can become difficult to distinguish between S3 and S4 thus producing a single sound called a summation gallop.

Causes
S4 is caused by the atria contracting forcefully in an effort to overcome an abnormally stiff or hypertrophic ventricle. This causes abnormal turbulence in the flow of blood that can be detected by a stethoscope.

Associations
The S4 heart sound is associated with any process that increases the stiffness of the ventricle, including:
 * hypertrophy of the ventricle
 * long-standing hypertension (causes ventricular hypertrophy)
 * aortic stenosis (causes ventricular hypertrophy)
 * overloading of the ventricle (causes ventricular hypertrophy)
 * fibrosis of the ventricle (e.g. post-MI)

Treatment
The S4 heart sound itself does not require treatment; rather plans should be laid to stop the progression of whatever causes the underlying ventricular dysfunction. The S4 heart sound is a secondary manifestation of a primary disease process and treatment should be focused on treating the underlying, primary disease.