Antacid

An antacid is any substance, generally a base, which counteracts stomach acidity. In other words, antacids are stomach acid neutralisers.

Action mechanism
Antacids relieve the pain of peptic ulcers. They perform a neutralization reaction, i.e. they buffer gastric acid, raising the pH to reduce acidity in the stomach. When the gastric hydrochloric acid reaches the nerves in the gastrointestinal mucosa, they signal pain to our central nervous system. This happens when these nerves are exposed, like in ulcers. The gastric acid may also reach ulcers in the esophagus or the duodenum.

Other mechanisms may contribute, such as the effect of aluminum ions inhibiting smooth muscle cell contraction and delaying gastric emptying.

Indications
Antacids are taken by mouth to relieve heartburn (the major symptom of gastroesophageal reflux disease), or acid indigestion. Treatment with antacids alone is symptomatic and only justified for minor symptoms. Peptic ulcers may require H2-receptor antagonists or proton pump inhibitors.

The usefulness of many combinations of antacids is not clear, although the combination of magnesium and aluminum salts may prevent alteration of bowel habits.

Some associations containing bismuth salts (which may cause encephalopathy) or an anticholinergic substance are not advised.

Side effects

 * Aluminum hydroxide: may lead to the formation of insoluble aluminum-phosphate-complexes, with a risk for hypophosphatemia and osteomalacia. Although aluminum has a low gastrointestinal absorption, accumulation may occur in the presence of renal insufficiency. Aluminum-containing drugs may cause obstipation.
 * Magnesium hydroxide: has laxative properties. Magnesium may accumulate in patients with renal failure leading to hypermagnesemia, with cardiovascular and neurological complications.
 * Carbonate: regular high doses may cause alkalosis, which in turn may result in altered excretion of other drugs, and kidney stones. A chemical reaction between the carbonate and hydrochloric acid may produce carbon dioxide gas. This causes gastric distension which may not be well tolerated.
 * Calcium: compounds containing calcium may increase calcium output in the urine, which might be associated to renal stones. Calcium salts may cause obstipation.
 * Sodium: increased intake of sodium may be deleterious for arterial hypertension, heart failure and many renal diseases

Interactions
Altered pH or complex formation may alter the bioavailability of other drugs (e.g. tetracycline). Urinary excretion of certain drugs may be influenced.

Drug names
Examples of antacids (the brands listed may not be available outside the USA).
 * Aluminum hydroxide (Amphojel®, AlternaGEL®)
 * Magnesium hydroxide (Phillips&#8217;® Milk of Magnesia)
 * Aluminum hydroxide and magnesium hydroxide (Maalox®, Mylanta®)
 * Aluminum carbonate gel (Basajel®)
 * Calcium carbonate (Tums®, Titralac®, Calcium Rich Rolaids®, Rennie®, Alcalak®)
 * Sodium bicarbonate (Bicarbonate of soda, Alka-Seltzer®)
 * Hydrotalcite (Mg6Al2(CO3)(OH)16 · 4(H2O); Talcid&reg;)

Antazidum Antiácido Antacidum Antacidum ยาลดกรด Antiasitler