5-methylcytosine - a methylated form of the nucleobase cytosine occurring predominantly in cytosine-phosphate-guanine (cpg) islands that are produced by dna methyltransferases and may regulate gene expression. Like cytosine, the dna sequence containing 5-methylcytosine (5-mc) is able to be replicated without error and 5-mc can pair with guanine in double stranded dna. However, dna sequences containing a high local concentration of 5-mc may be less transcriptionally active than areas with higher ratios of unmodified cytosine. Also see 5-methylcytosine
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