Aldophosphamide

From WikiMD free medical encyclopedia
Jump to: navigation, search

Aldophosphamide is a tautomer of the main active metabolite of the alkylating antineoplastic agent cyclophosphamide - the 4-hydroxycyclophosphamide. Some of the aldophosphamide is then intracellularly hydrolyzed by the enzyme phosphatase to the of the two directly cytotoxically active metabolites - phosphoramide mustard and acrolein - in the metabolic activation pathway of the cyclophosphamide. But most of the aldophosphamide undergoes metabolic inactivation, catalyzed by another enzyme, ALDH, which gives rise to carboxycyclophosphamide.

Aldophosphamide residue is a component in molecules of some new oxazaphosphorine anticancer drugs that are now underway in clinical and preclinical testing: the NSC 612567 (aldophosphamide perhydrothiazine) and NSC 613060 (aldophosphamide thiazolidine).[1]

References

Also see the following articles on Aldophosphamide

Metabolic.jpg

Featured disease

Metabolic syndrome is a cluster of the most dangerous heart attack risk factors: diabetes and prediabetes, abdominal obesity, high triglycerides, low HDL cholesterol and high blood pressure.

Affects one in three adults

Affecting about 35 percent of all adults in the United States according to the CDC, metabolic syndrome contributes to weight gain, by causing a state of internal starvation called metabolic starvation. This in turn leads to increases hunger, sugar cravings and increased portions leading to overeating and weight gain.

Cause and effect misunderstood

Since we traditionally thought that the portion control (which in turn was attributed wrongly to poor will power)is the cause of weight gain, rather than the effect of this metabolic starvation, all our traditional ideas about cause and effect of obesity were not only wrong but lead to the “blame the victim” attitude when it comes to obesity.

Secret of weight gain revealed

Secret of weight gain, and metabolic syndrome revealed - it has been recently proven that metabolic syndrome, and the weight gain itself are caused by a process called insulin resistance. Check your metabolic syndrome risk using the free Metabolic syndrome meter. Watch this amazing Ted Med video that reveals the secret of weight loss - Stop blaming the victim for obesity


Template:Chemotherapeutic agents

Template:Antineoplastic-drug-stub Comprehensive list of medications or pharmaceutical drugs used in the United States with their NDC or national drug code, brand name, dosage, forms of administration etc. sorted alphabetically.

List of FDA approved pharmaceutical drugs/medications sorted alphabetically

Comprehensive list of United States Food and Drug Administration approved [[drug]s / [[medication]s sorted alphabetically.

List of FDA approved drugs sorted alphabetically

ABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 | Canadian drugs


Portions of content adapted from Wikipedias article on Aldophosphamide licensed under GNU FDL.


Cite error: <ref> tags exist, but no <references/> tag was found

WikiMD Sponsors - W8MD Weight Loss, Sleep and MedSpa Centers

Pronounced weightMD, our state of the art W8MD weight loss, sleep, holistic IV nutrition and aesthetic medicine programs can help you not only to lose weight, and sleep better but also look your best! Since its inception in 2011, W8MD’s insurance physician weight loss program has successfully helped thousands of patients.

W8MD Weight Loss

W8MD’s Physician weight loss is unique in many ways with a comprehensive multidisciplinary approach to weight loss. Weight Loss Success Stories....

W8MD Sleep Services

Sleep medicine program uses state of the art technology to diagnose and treat over 80 different sleep disorders. W8MD Sleep Services…

W8MD Medical Aesthetic Services

Medical aesthetic program offers a wide variety of advanced laser skin treatments including oxygen super facials, photofacials and Affordable Botox. W8MD Aesthetic Services…

IM and IV nutrition therapy includes booster shots for B12, vitamin B complex, Vitamin C, Detox treatments and IV nutrition therapy. W8MD IV Nutrition…

W8MD weight loss | Philadelphia medical weight loss | NYC medical weight loss | NJ medical weight loss

W8MD Weight Loss, Sleep & Medical Aesthetics

Intro to W8MD Weight Loss, Sleep & Medical Aesthetics


Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate and or incorrect. Use the information on this wiki at your own risk! See full Disclaimers.WikiMD is supported by W8MD Weight loss, Poly-Tech Sleep & Medical Aesthetic Centers of America.