Aldophosphamide

From WikiMD free wellness and medical encyclopedia
Jump to: navigation, search

Aldophosphamide is a tautomer of the main active metabolite of the alkylating antineoplastic agent cyclophosphamide - the 4-hydroxycyclophosphamide. Some of the aldophosphamide is then intracellularly hydrolyzed by the enzyme phosphatase to the of the two directly cytotoxically active metabolites - phosphoramide mustard and acrolein - in the metabolic activation pathway of the cyclophosphamide. But most of the aldophosphamide undergoes metabolic inactivation, catalyzed by another enzyme, ALDH, which gives rise to carboxycyclophosphamide.

Aldophosphamide residue is a component in molecules of some new oxazaphosphorine anticancer drugs that are now underway in clinical and preclinical testing: the NSC 612567 (aldophosphamide perhydrothiazine) and NSC 613060 (aldophosphamide thiazolidine).[1]

References

Metabolic.jpg

Featured disease

Metabolic syndrome is a cluster of the most dangerous heart attack risk factors: diabetes and prediabetes, abdominal obesity, high triglycerides, low HDL cholesterol and high blood pressure.

Affects one in three adults

Affecting about 35 percent of all adults in the United States according to the CDC, metabolic syndrome contributes to weight gain, by causing a state of internal starvation called metabolic starvation. This in turn leads to increases hunger, sugar cravings and increased portions leading to overeating and weight gain.

Cause and effect misunderstood

Since we traditionally thought that the portion control (which in turn was attributed wrongly to poor will power)is the cause of weight gain, rather than the effect of this metabolic starvation, all our traditional ideas about cause and effect of obesity were not only wrong but lead to the “blame the victim” attitude when it comes to obesity.

Secret of weight gain revealed

Secret of weight gain, and metabolic syndrome revealed - it has been recently proven that metabolic syndrome, and the weight gain itself are caused by a process called insulin resistance. Check your metabolic syndrome risk using the free Metabolic syndrome meter. Watch this amazing Ted Med video that reveals the secret of weight loss - Stop blaming the victim for obesity


Template:Chemotherapeutic agents

Template:Antineoplastic-drug-stub Comprehensive list of medications or pharmaceutical drugs used in the United States with their NDC or national drug code, brand name, dosage, forms of administration etc. sorted alphabetically.

See also

External links

The following is the collection of detailed information and links to the National Institute of Health (NIH) comprehensive drug information portal and other reliable sources of information. Select the drug name below to show drug description, drug classification, other common drug names, and information on the reasons why prescribed, how medication should be used, and what possible side effects could occur.

Drug names

A • B • C • D • E • F • G • H • I • J • K • L • M • N • O • P • Q • R • S • T • U • V • W • X • Y • Z

Search for other drug names not listed above Portions of content adapted from Wikipedias article on Aldophosphamide licensed under GNU FDL.
Cite error: <ref> tags exist, but no <references/> tag was found

WikiMD Sponsors: W8MD Weight Loss, Sleep & Medical Aesthetics


Tired of being overweight or obese? W8MD's insurance weight loss program can HELP

  • W8MD IV Nutrition: Our IM and IV nutrition therapy includes booster shots for B12, vitamin B complex, Vitamin C, Detox treatments and IV nutrition therapy. learn more…
W8MD weight loss locations: Philadelphia weight loss | King of Prussia, PA weight loss | NYC weight loss | NJ weight loss

Medical Aesthetics

Contact us (718) 946-5501 | Why advertise on WikiMD?


Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate and or incorrect. Use the information on this wiki at your own risk! See full Disclaimers.WikiMD is supported by W8MD Weight loss, Poly-Tech Sleep & Medical Aesthetic Centers of America.