Information about Atropine
Atropine is a natural alkaloid anticholinergic agent that has potent antimuscarinic effects and is used by injection to treat symptomatic bradycardia, severe bronchospasm and to reduce vagal stimulation.
Liver safety of Atropine
Atropine has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.
Mechanism of action of Atropine
Atropine (at' roe peen) is a natural alkaloid that is the prototypic anticholinergic agent found as a secondary metabolite in plants of the Solanaceae family, including deadly nightshade (atropa belladonna) for which it is named. Atropine has potent and broad, nonspecific antimuscarinic activity. Because of its rapid onset of action and short half-life, atropine is used parenterally in management of medical emergencies including cardiac bradyarrhythmias, during anesthesia to prevent vagal reflexes and to decrease secretions, for acute bronchospasm, and for anticholinesterase overdose or poisoning. Oral formulations of atropine are present in many over the counter and combination products used for allergic rhinitis and symptoms of peptic ulcer disease.
FDA approval information for Atropine
Atropine has been in use in medicine for decades, but has not been formally approved for many of its broadly accepted indications. Atropine is used in low doses (1 mg or less) and usually for short periods of time. Homatropine (hoe mat' roe peen) is a synthetic derivative of Atropine and is less potent and has a shorter half-life, which makes it appropriate as a cycloplegic eye drops to dilate the pupils. It is also used in combination with opiate drugs for its aversive side effects to prevent abuse of high doses.
Side effects of Atropine
Common side effects of atropine are those of parasympathetic stimulation and include dryness of the mouth and eyes, decreased sweating, hyperthermia, headache, visual blurring, constipation, urinary retention, impotence, tachycardia and palpitations, anxiety, restlessness and in some instances [[agitation]] and hallucinations. Anticholinergic agents can precipitate acute narrow angle glaucoma and acute urinary retention.