Bupropion

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Information about Bupropion

Bupropion is an aminoketone antidepressant that is widely used in therapy of depression and smoking cessation.

Liver safety of Bupropion

Bupropion therapy can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.

Mechanism of action of Bupropion

Bupropion (bue proe' pee on) is an aminoketone derivative and antidepressant whose mechanism of action is not well understood. Bupropion has no activity against monamine oxidase and only weak inhibition of serotonin and norepinephrine reuptake. It appears to act via noradrenergic or dopaminergic mechanisms.

FDA approval information for Bupropion

Bupropion was approved for use in moderate and severe depression in the United States in 1985 and was later approved for use in seasonal affective disorder and in aiding smoking cessation.

Brand name for Bupropion

Bupropion is currently in wide use, approximately 4 million prescriptions being filled yearly. Bupropion is available as immediate and sustained release tablets of 75, 100, 150, 200 and 300 mg in several generic forms and under the brand name of Welbutrin.

Dosage and administration for Bupropion

The recommended dosage for depression in adults is 75 to 300 mg daily either twice daily in immediate release forms or once daily in extended or sustained release forms. Separate formulations of sustained release forms are available for smoking cessation in tablets of 150 mg generically and under the brand name Zyban, recommended dosage being 150 to 300 mg daily.

Side effects of Bupropion

Common side effects of bupropion are drowsiness, dizziness, agitation, headahce, nausea, abdominal pain and dry mouth.

The following are antidepressant subclasses and drugs

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone


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