View source for Dicyclomine

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{{intro}}
Dicyclomine is an anticholinergic agent used to treat gastrointestinal conditions such as acid peptic disease and irritable bowel syndrome. 

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{{livtox}}
Dicyclomine has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury.

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{{moa}}
Dicyclomine (dye sye' kloe meen) is synthetic tertiary amine, antispasmotic and anticholinergic agent which inhibits the muscarinic actions of [[acetylcholine]] on autonomic nerve endings, decreasing gastrointestinal secretions and intestinal motility. Dicyclomine has broad activity against muscarinic [[acetylcholine]] receptors, but has been used largely for gastrointestinal conditions including peptic ulcer disease and gastrointestinal conditions associated with pain and spasm. 

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{{fda}}
Dicyclomine was approved for use in the United States for the treatment of peptic ulcer disease in 1996, but is now more commonly used as an antispasmotic to treat irritable bowel syndrome. Dicyclomine is available in capsules and tablets of 10 and 20 mg generically and under the brand name Bentyl. Oral syrups and solutions for injection are also available. 

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The typical oral dose in adults is 10 to 20 mg four times daily. 

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{{se}}
Common side effects are those of parasympathetic stimulation and include dryness of the mouth and eyes, decreased sweating, [[headache]], [[visual blurring]], [[constipation]], [[urinary retention]], [[anxiety]], [[restlessness]] and [[delusions]]. Anticholinergic agents can precipitate acute narrow angle glaucoma and acute [[urinary retention]].


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