Flibanserin

From WikiMD
Jump to navigation Jump to search

Information about Flibanserin

Flibanserin is a serotonergic antidepressant used to treat hypoactive sexual desire disorder.

Liver safety of Flibanserin

Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment, but has not been linked to instances of clinically apparent acute liver injury.

Mechanism of action of Flibanserin

Flibanserin (flib an' ser in) is a serotonergic mixed agonist and antagonist that was initially developed as an antidepressant when it was found to have possible effects on sexual desire and drive. In vitro, flibanserin acts predominantly as a serotonin (5-HT) 1A receptor agonist, but it also has antagonist activity against other serotonin receptors, such as 5-HT 2C and 2B, as well as less defined activity at dopamine D4 receptors. Flibanserin also has variable regional activities, increasing or decreasing serotonin, dopamine and norepinephrine in different brain areas. While its exact mechanism of action is unclear, flibanserin was found to improve subjective measures of sexual desire and satisfaction in multiple large clinical trials done mostly in premenopausal women who fulfilled the clinical criteria for hypoactive sexual desire disorder.

FDA approval information for Flibanserin

Flibanserin was approved for use in the United States in 2015 for use in treatment of hypoactive sexual desire disorder in premenopausal women. There is limited clinical experience with its use. Concurrent alcohol use is considered contraindicated when taking flibanserin, and caution is recommended against its use with antidepressants or sedatives and in patients wtih hepatic impairment.

Dosage and administration for Flibanserin

Flibanserin is available in tablets of 100 mg under the commercial name Addyi. The recommended dose is 100 mg once daily at bedtime.

Side effects of Flibanserin

Common side effects include dizziness, fatigue, somnolence, insomnia, nausea and drug mouth. Less common, but potentially serious side effects include hypotension, syncope and next day somnolence or sedation. Because of the severity of these adverse events, flibanserin is available only as a part of a rigorous Risk Evaluation and Mitigration Strategy (REMS) that requires registration, certification of the prescribers and pharmacies, and regular reporting.

The following are antidepressant subclasses and drugs

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone


Cost and Coupons - Flibanserin

Reviews for Flibanserin


WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Articles on Flibanserin

This article is a stub. YOU can help Wikimd by expanding it!

Learn more about Flibanserin

Drug classes


WikiMD Resources for Flibanserin

The following chart shows the WikiMD resources in a 360 degree point of view bringing together resources from scientific articles to social media.

Social Media on Flibanserin

W8md weight loss
W8MD weight loss
Reddit
Quora.png
Pins
Instagram
YouTube videos
Flickr
Bing.png

Recent Articles

Most recent articles for Flibanserin:

Most Cited:

Review Articles:

Magazine Articles:

Media & Blogs

Media articles for Flibanserin:

Books and news:

Commentary:


Health Topics A-Z:
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | View All Health Topics in one page! | Popular health topics

Scientific Articles

Evidence based medicine for Flibanserin:

Clinical trials for Flibanserin:

Resources & Links

Patient resources for Flibanserin:

External - W8MD A-Z list of topics:
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U |V | W | X | Y | Z

  • According to Peter Frishauf, founder of Medscape, wiki is the future of medicine!
  • Knowledge is power. Let us empower the people! Join WikiMD and be an editor.
W8MD logo

Ad. Tired of being overweight?. W8MD's insurance weight loss can HELP*

Lose weight King of Prussia, PA | Lose weight NYC | Lose weight NJ | Lose weight Philadelphia | Advertise

Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer. * Individual results may vary for weight loss from our sponsors.

Our sponsors WikiMD is supported by W8MD weight loss, sleep and medical aesthetic centers.