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Information about Fluvoxamine

Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) used in the therapy of obsessive-compulsive disorder.

Liver safety of Fluvoxamine

Fluvoxamine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury.

Mechanism of action of Fluvoxamine

Fluvoxamine (floo vox' a meen) is a selective serotonin reuptake inhibitor (SSRI) that was developed largely for use in obsessive-compulsive disorder. Fluvoxamine acts by blocking the reuptake of serotonin in CNS synaptic clefts, thus increasing serotonin levels in the brain which is associated with its psychiatric effects.

FDA approval information for Fluvoxamine

Fluvoxamine was approved for use in obsessive-compulsive disorder in 1994 in the United States and is used in both adults and children above the age of 8 years. It is also used for social anxiety disorder, but not specifically for depression or bipolar disorders.

Dosage and administration for Fluvoxamine

Fluvoxamine is available as tablets of 25, 50 and 100 mg in multiple generic forms and under the brand name of Luvox. Extended release forms are also available in doses of 100 and 150 mg. The recommended dosage in adults is 50 mg once daily, increasing to a maximum of 300 mg. The dosage in children is 25 mg daily, increasing to a maximum of 200 to 300 mg based upon age below or above 11 years.

Side effects of Fluvoxamine

Common side effects are drowsiness,dyspepsia, nausea, headache, increased sweating, increased appetite, weight gain and sexual dysfunction.

The following are antidepressant subclasses and drugs

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone

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