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Information about Heroin

Heroin and opium are potent opiates that are currently banned in the United States and considered drugs of abuse.

Liver safety of Heroin

Persons who actively use heroin or opium often have liver disease due to substance abuse (alcoholic liver injury) or injection drug use (chronic hepatitis B, D or C), but neither heroin nor opium have been convincingly linked to clinically apparent liver injury or worsening of a concurrent liver disease.

Mechanism of action of Heroin

Opium (o pee’ um) is a mixture of natural alkaloids derived from resin extracts from the seeds of the opium poppy, Papaver somniferum. The analgesic and mood altering effects of poppy extracts have been known for centuries and opium use has had profound effects on world history and many human lives. The natural opiates in opium include morphine, codeine and thebaine. Opium is typically taken by inhalation (opium pipe), but can also be taken orally.

History of Heroin

Heroin (morphine diacetate) was developed in the 19th century as a derivative of morphine, the major alkaloid constituent of opium, and was initially thought to provide the potent analgesic effects without the euphoria and risk of psychological and physical dependency characteristic of opium. Heroin was the brand name for morphine diacetate and initially was sold over-the-counter as a cough suppressant. The abuse potential of heroin, however, rapidly became obvious and, by the 1920’s, heroin was the major drug of abuse in the United States, which led to its being made illegal and banned from clinical medicine. Both heroin and opium are potent agonists of the opiate receptors (predominantly the µ type receptor) which are found mostly in the central nervous system, but also in the lungs, heart, gastrointestinal tract and even on circulating white blood cells.

Clinical effects of Heroin

Opium and heroin have many clinical effects, most strikingly euphoria, drowsiness, mental clouding and analgesia. While banned in the United States, heroin (known as its more correct chemical name of morphine diacetate) is available in other countries including the United Kingdom, but its use is severely restricted. The severe complications of heroin use are usually not due to its side effect profile, but to the unreliable sources, concentration and quality of the product.

Full and partial opiod agonists:

Opiate antagonists:

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