Homeostatic model assessment

From WikiMD
Jump to navigation Jump to search

The homeostatic model assessment (HOMA) is a method used to quantify insulin resistance and beta-cell function. It was first described under the name HOMA by Matthews et al. in 1985.

Derivation

The HOMA authors used data from physiological studies to develop mathematical equations describing glucose regulation as a feedback loop. [1] They published computer software that solves the equations, so that insulin resistance and β-cell function can be estimated from fasting glucose and insulin levels. They also published an equation (see below) that gave approximately the same answers as an early version of the computer software. [2]

The computer model has since been improved to a HOMA2 model[3] to better reflect human physiology and recalibrated to modern insulin assays. In this updated version it is possible to determine insulin sensitivity and β-cell function from paired fasting plasma glucose and radioimmunoassay insulin, specific insulin, or C-peptide concentrations. The authors recommend the computer software be used wherever possible. [4] [5]

Notes

The HOMA model was originally designed as a special case of a more general model called HOMA-CIGMA.[6]

The approximating equation for insulin resistance, in the early model, used a fasting plasma sample, and was derived by use of the insulin-glucose product, divided by a constant: (assuming normal-weight, normal subjects < 35 years, having 100% β-cell function an insulin resistance of 1)

<math>\text{HOMA-IR} = \frac{\text{Glucose} \times \text{Insulin}}{22.5}</math> <math>\text{HOMA-IR} = \frac{\text{Glucose} \times \text{Insulin}}{405}</math>
<math> \text{HOMA-}\beta = \frac{20 \times \text{Insulin}}{\text{Glucose}-3.5} %</math> <math> \text{HOMA-}\beta = \frac{360 \times \text{Insulin}}{\text{Glucose}-63} %</math>
Glucose in Molar Units mmol/L Glucose in mass units mg/dL

IR is insulin resistance and is the β-cell function. Insulin is given in mU/L. Glucose and insulin are both during fasting.[2]

This model correlated well with estimates using the euglycemic clamp method (r = 0.88).[2]

The authors have tested HOMA extensively against other measures of insulin resistance (or its reciprocal, insulin sensitivity) and β-cell function.[4] [7] [8]

References

Metabolic.jpg

Featured disease

Metabolic syndrome is a cluster of the most dangerous heart attack risk factors: diabetes and prediabetes, abdominal obesity, high triglycerides, low HDL cholesterol and high blood pressure.

Affects one in three adults

Affecting about 35 percent of all adults in the United States according to the CDC, metabolic syndrome contributes to weight gain, by causing a state of internal starvation called metabolic starvation. This in turn leads to increases hunger, sugar cravings and increased portions leading to overeating and weight gain.

Cause and effect misunderstood

Since we traditionally thought that the portion control (which in turn was attributed wrongly to poor will power)is the cause of weight gain, rather than the effect of this metabolic starvation, all our traditional ideas about cause and effect of obesity were not only wrong but lead to the “blame the victim” attitude when it comes to obesity.

Secret of weight gain revealed

Secret of weight gain, and metabolic syndrome revealed - it has been recently proven that metabolic syndrome, and the weight gain itself are caused by a process called insulin resistance. Check your metabolic syndrome risk using the free Metabolic syndrome meter. Watch this amazing Ted Med video that reveals the secret of weight loss - Stop blaming the victim for obesity


External links



WikiMD Resources for Homeostatic model assessment

Articles

Most recent articles

Most cited

Review articles

Articles on Homeostatic model assessment in N Eng J Med, Lancet, BMJ

Media Homeostatic model assessment

Powerpoint slides

Podcasts and MP3's

Videos

Evidence Based Medicine

Cochrane Collaboration

Clinical Trials

Ongoing Trials on Homeostatic model assessment

Trial results on Homeostatic model assessment

Clinical Trials on Homeostatic model assessment at Google

Books and news

Books on Homeostatic model assessment

Homeostatic model assessment in the news

Commentary Homeostatic model assessment

Blogs on Homeostatic model assessment

Patient Resources / Community

Patient resources

Discussion groups

Patient Handouts

Other resources

Social Media

Reddit
Quora.png
Pins
Instagram
YouTube videos
Flickr
Bing.png

W8MD Weight Loss, Sleep & MedSpa

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U |V | W | X | Y | Z



W8md2.jpg

World's largest food, health, weight loss, wellnesspedia and encyclopedia

If you are a medical professional or an expert in any field of medicine, please join us in building the world's largest weight loss and wellness encyclopedia created by experts in the field, not by the crowd. WikiMD is sponsored by W8MD weight loss, sleep and medical aesthetic centers


W8MD Weight Loss, Sleep & Medical Aesthetic Centers

Since its inception in 2011, W8MD’s insurance physician weight loss program has successfully helped thousands of patients succeed in not only losing weight but also keep it off with an ongoing maintenance plan.

FANTASTIC PROGRAM. TRULY A LIFE CHANGER. D.M. LOST 100 LBS^^

weight loss success stories

^^Individual results may vary.

Weight-loss.jpg

W8MD weight loss, sleep and medical spa blogs


Support our sponsors

W8MD weight loss, sleep and medspa centers sponsors WikiMD.

W8MD's Locations for losing weight, sleeping better and looking your best

Philadelphia

weight loss Philadelphia | Sleep center Philadelphia

King of Prussia

Lose weight King of Prussia | sleep doctor King of Prussia

New York

Weight loss NYC | Fast weight loss NYC | Lose weight NYC | Sleep apnea NYC

New Jersey

New Jersey Weight Loss, Sleep and Medical Spa Cherry Hill NJ

Other W8MD blogs

Lorcaserin weight loss | Qsymia weight loss | Phentermine weight loss | Weight loss blog | Free weight loss | Saxenda weight loss | Contrave weight loss


This article is a stub. YOU can help Wikimd by expanding it!

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.

Diet | Weight loss | Obesity | Metabolic syndrome | Glossary of dietary supplements

Places for Homeostatic model assessment

  • W8MD’s insurance weight loss programs one of the best ways to lose weight fast in NYC, King Of Prussia, Philadelphia, New Jersey and other places.

W8mdlogo.png
Tired of being overweight? W8MD can help


W8MD Weight Loss, Sleep & Aesthetic Services

Pennsylvania

Call 215-676-2334

New York

2632 E 21st Street Ste L2 Brooklyn New York 11235.

Call 718-946-5500

New Jersey

  • W8MD Weight Loss, Sleep & MedSpa in Cherry Hill, NJ at 140 E. Evesham Road, Cherry Hill, NJ 08003.

Call 800-W8MD-007

W8MD weight loss | Philadelphia medical weight loss | NYC medical weight loss


W8MD's insurance weight loss program

W8MD can help?

W8md-short.jpg

W8MD’s insurance medical weight loss program is one of the best ways to lose weight fast in NYC, King Of Prussia, Philadelphia, New Jersey and other places.

  • Our weight loss program is based on clinically proven measures to help you lose weight.
  • Our experienced weight loss doctors understand the complex causes of weight gain.
  • We use the best tools to help burn fat fast and effectively unlike many fad diets that make you lose weight by losing muscle.
  • We offer delicious, low cost and affordable weight loss supplements or meal replacements to help reduce caloric intake and burn fat.
  • We offer FDA approved weight loss medications or diet pills to help control hunger, reduce cravings and burn unhealthy fat.

Prab R. Tumpati, MD Founder, WikiMD & W8MD

Dr Tumpati is a board certified physician with significant practice experience in managing sleep disorders, internal medicine, aesthetic and obesity medicine. As one of the few physicians that have the privilege of a fellowship training in Obesity Medicine, Dr Tumpati is very passionate about educating the public and physicians about how some of the nutritional concepts were misunderstood. As the founder of W8MD Weight Loss, Sleep and MedSpa centers, Dr Tumpati is the medical director for the New York, New Jersey and Pennsylvania locations and commutes weekly between the locations.

Popular weight loss searches

  1. 2.0 2.1 2.2
  2. 4.0 4.1
  3. Turner et al. (1993) Measurement of insulin resistance and β-cell function: the HOMA and CIGMA approach. Current topics in diabetes research (eds) F. Belfiore, R. Bergman and G. Molinatti Front Diabetes. Basel, Karger 12: 66-75

Ad. Tired of being overweight? W8MD's insurance weight loss* program can HELP | Advertise on WikiMD

Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer. * Individual results may vary.