Nortriptyline

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Information about Nortriptyline

Nortriptyline is a tricyclic antidepressant that is also used in smoking cessation.

Liver safety of Nortriptyline

Nortriptyline can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute and chronic cholestatic liver injury.

Mechanism of action of Nortriptyline

Nortriptyline (nor trip' ti leen) is a tricyclic antidepressant which acts by inhibition of reuptake of serotonin and norepinephrine in synaptic clefts, thus increasing brain levels of these neurotransmitters. Nortriptyline

FDA approval information for Nortriptyline

Nortriptyline was approved for use in the United States in 1964 for the treatment of depression.

Dosage and administration for Nortriptyline

It is also used for smoking cessation and is commonly used in the United States, with more than 3 million prescriptions being filled yearly. Nortriptyline is available in generic forms and under the brand names of Aventyl and Pamelor in 10, 25, 50 and 75 mg tablets. An oral solution is also available. The typical recommended dose for depression is 25 mg three or four times daily, increasing based upon effect and tolerance to as much as 150 mg daily. The typical dose for smoking cessation is 25 mg daily, gradually increasing to a maximum of 100 mg daily.

Side effects of Nortriptyline

Common side effects include drowsiness, dizziness, restlessness, headache, blurred vision, dry mouth, constipation, and urinary retention.

The following are antidepressant subclasses and drugs

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone


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