Phentermine

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Phentermine is controlled substance and an appetite suppressant weight loss medication or diet pill that has been on the market for over 50 years in the United States. Approved by the US FDA in 1959, Phentermine has been on the market for a long time with proven safety record. Phentermine is used for a limited period of time to speed weight loss in overweight people who are exercising and eating a low-calorie diet. Phentermine is in a class of medications called anorectics. It works by decreasing appetite. Phentermine comes as tablets and extended-release capsules. It usually is taken as a single daily dose in the morning or three times a day 30 minutes before meals.

Indications for Phentermine

­ADIPEX-P® is a sympathomimetic amine anorectic weight loss medication indicated as a short-term adjunct in a regimen of weight decrease based on exercise, behavioral modification and caloric limit in the management of exogenous obesity for patients with:

Adverse effects of Phentermine

Phentermine is generally well tolerated and most people may not experience any major side effects.

Treatment should be discontinued inpatients who develop new, unexplained symptoms of dyspnea, angina pectoris, syncope or smaller extremity edema, and patients should be evaluated for the possible occurrence of pulmonary hypertension.

Common (1% or more in incidence) adverse effects include:

  • Xerostomia (dry mouth)
  • Restlessness
  • Nervousness
  • Euphoria
  • Agitation
  • Arrhythmia
  • Tachycardia
  • Hypertension
  • Diarrhea
  • Vomiting
  • Headache
  • Rash
  • Urinary frequency
  • Facial oedema
  • Unpleasant taste
  • Urticaria
  • Impotence
  • Changes in libido

Rare (1% or less incidence) adverse effects include:

  • Primary pulmonary hypertension
  • Valvular heart disease (in combination with dexfenfluramine and fenfluramine; causal relationship unclear)
  • Increased seizure activity in people with epilepsy
  • Psychosis
  • Withdrawal symptoms on stopping
  • Dysphoria
  • Ischaemic events

Weight loss medications

In 2012, the FDA approved two new weight loss medications Qsymia and Belviq after years of rejecting many other weight loss medications. There are other traditional and time tested weight loss medications such as Phentermine, Phendimetrazine etc.

What works and what does not for losing weight?

New weight loss medications Qsymia and Belviq

weight loss videos

Cautions and interactions

Phentermine use is contraindicated in those who are: Known hypersensitivity or idiosyncratic reaction to sympathomimetic amines Taking amphetamine (i.e., Adderall, Dexedrine, Vyvanse), dexfenfluramine, fenfluramine, furazolidone, guanadrel, guanethidine, or have taken a monoamine oxidase inhibitor (MAOI) (e.g., phenelzine) in the last 14 days Hyperthyroidism Glaucoma Peptic ulcer Prostatic hypertrophy Epilepsy Simultaneous treatment with drugs that increase blood pressure Contraindicated in cardiac disease (e.g. advanced arteriosclerosis, pulmonary hypertension, uncontrolled hypertension, arrhythmias) and cerebrovascular disease (stroke) Pregnant, planning to become pregnant, or are breast-feeding Those receiving serotonergic medications such as the selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitor, tricyclic antidepressant, due to the potential for serotonin syndrome to be precipitated by the treatment.

Mechanism of action

It is believed to suppress the appetite and increases the metabolism by its actions on the appetite center

Dosing and administration

It is available in 15 mg, 30 mg and 37.5 mg in tablet and capsule form.

Brand names available

  • Adipex P (immediate release)
  • Anoxine-AM
  • Ionamin (slow-release resin, Australia, discontinued in the US)
  • Mirapront
  • Obephen
  • Obermine
  • Obestin-30
  • Phentermaxx
  • Phentrol
  • Phenterex
  • Phentromin
  • Pro-Fast SA
  • Qsymia (with topiramate)
  • Redusa
  • Panbesy
  • Phentermine Trenker
  • Obenix
  • Oby-Trim
  • Teramine
  • Zantryl
  • Suprenza (disintegrates orally)

Phentermine and Topiramate

Phentermine is often combined with Topiramate like in the brand name Qsymia for better weight loss results, mitigate some of the side effects, and increase effectiveness. In fact, in a large 30,000 patient diet pill comparison study published in JAMA that compared new prescription weight loss medications or diet pills, Qsymia was considered the most effective weight loss prescription medication.

Locations for Physicians that prescribe

 

WikiMD Resources 360 - Phentermine
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Scientific articles to social media

Articles

Policies / Guidelines
  1. Most recent articles
  2. Most cited articles
  3. Review articles
  4. in N Eng J Med, Lancet, BMJ
  1. US National Guidelines Clearinghouse
  2. NICE Guidance
  3. FDA on Phentermine
  4. CDC on Phentermine

Media articles

Patient Resources / Community
  1. Powerpoint Slides
  2. Google Images | Yale images
  3. Podcasts & MP3s
  4. Videos
  1. Patient Resources
  2. Discussion groups
  3. Patient Handouts
  4. Doctors for Phentermine

Evidence Based Medicine

Healthcare Provider Resources
  1. Cochrane Collaboration
  2. Bandolier
  3. TRIP
  4. Edidence Based Medicine
  1. Condition/symptom
  2. Causes & Risk Factors
  3. Tests/studies
  4. Treatment

Clinical Trials

News
  1. Ongoing Clinical Trials
  2. Trial results
  3. Clinical Trials at Google
  1. Phentermine in the news
  2. Be alerted on news
  3. News trends

Definition - Phentermine

Social media posts - Phentermine
  1. Definitions
Flickr

Books on the topic

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  1. Books on Phentermine
  2. Amazon on Phentermine
Facebook posts
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Continuing medical education (CME)

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  1. CME Programs
Tweets
Commentary & Blogs
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  1. Blogs
  2. Commentary
  3. FAQ
  4. .Gov
  5. PDF files
YouTube videos
Pins
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Reddit
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