Systemic disease

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A systemic disease is one that affects a number of organs and tissues, or affects the body as a whole.[1]

Examples

Detection

Getting a regular eye exam may play a role in identifying the signs of some systemic diseases. "The eye is composed of many different types of tissue. This unique feature makes the eye susceptible to a wide variety of diseases as well as provides insights into many body systems. Almost any part of the eye can give important clues to the diagnosis of systemic diseases. Signs of a systemic disease may be evident on the outer surface of the eye (eyelids, conjunctiva and cornea), middle of the eye and at the back of the eye (retina)."[2]

Since 500 B.C., some researchers have also believed that the physical condition of the fingernails and toenails can indicate various systemic diseases. Careful examination of the fingernails and toenails may provide clues to underlying systemic diseases, since some diseases have been found to cause disruptions in the nail growth process. The nail plate is the hard keratin cover of the nail. The nail plate is generated by the nail matrix located just under the cuticle. As the nail grows, the area closest to becoming exposed to the outside world (distal) produces the deeper layers of the nail plate, while the part of the nail matrix deeper inside the finger (proximal) makes the superficial layers. Any disruption in this growth process can lead to an alteration in the shape and texture.

Take pitting, for example. Pitting looks like depressions in the hard part of the nail. Pitting usually is associated with psoriasis, affecting 10 to 50 percent of patients with that disorder.[3] Pitting also may be caused by a variety of systemic diseases, including Reiter's syndrome and other connective tissue disorders, sarcoidosis, pemphigus, alopecia areata, and incontinentia pigmenti.[4] Because pitting is caused by defective layering of the superficial nail plate by the proximal nail matrix, any localized dermatitis (e.g., atopic dermatitis or chemical dermatitis) that disrupts orderly growth in that area also can cause pitting.[5]

See also

References

Metabolic.jpg

Featured disease

Metabolic syndrome is a cluster of the most dangerous heart attack risk factors: diabetes and prediabetes, abdominal obesity, high triglycerides, low HDL cholesterol and high blood pressure.

Affects one in three adults

Affecting about 35 percent of all adults in the United States according to the CDC, metabolic syndrome contributes to weight gain, by causing a state of internal starvation called metabolic starvation. This in turn leads to increases hunger, sugar cravings and increased portions leading to overeating and weight gain.

Cause and effect misunderstood

Since we traditionally thought that the portion control (which in turn was attributed wrongly to poor will power)is the cause of weight gain, rather than the effect of this metabolic starvation, all our traditional ideas about cause and effect of obesity were not only wrong but lead to the “blame the victim” attitude when it comes to obesity.

Secret of weight gain revealed

Secret of weight gain, and metabolic syndrome revealed - it has been recently proven that metabolic syndrome, and the weight gain itself are caused by a process called insulin resistance. Check your metabolic syndrome risk using the free Metabolic syndrome meter. Watch this amazing Ted Med video that reveals the secret of weight loss - Stop blaming the victim for obesity



WikiMD Resources for Systemic disease

Articles on Systemic disease

Govt. policies / Guidelines
  1. Most recent articles on Systemic disease
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  4. Articles on Systemic disease in N Eng J Med, Lancet, BMJ
  1. US National Guidelines Clearinghouse on Systemic disease
  2. NICE Guidance on Systemic disease
  3. FDA on Systemic disease
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Media articles Systemic disease

Patient Resources / Community
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  1. Patient resources
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Evidence Based Medicine

Healthcare Provider Resources
  1. Cochrane Collaboration on Systemic disease
  2. Bandolier on Systemic disease
  3. TRIP on Systemic disease
  4. Edidence Based Medicine on Systemic disease
  1. Symptoms of Systemic disease
  2. Causes & Risk Factors for Systemic disease
  3. Diagnostic studies for Systemic disease
  4. Treatment of Systemic disease

Clinical Trials

News on Systemic disease
  1. Ongoing Trials on Systemic disease at Clinical Trials.gov
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Definition of Systemic disease

Flickr on Systemic disease
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Continuing medical education (CME)

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