Whipple's disease

From WikiMD
Jump to navigation Jump to search

Whipple's disease is a rare disorder that has widespread effects on the body, including impaired absorption of nutrients, weight loss, joint pain, and anemia.

Cause of Whipple's disease

Caused by the bacterium Tropheryma whipplei, the disorder can affect any system in the body, including the brain, eyes, heart, joints, and lungs, but usually occurs in the gastrointestinal system.

Symptoms

Neurological symptoms occur in up to 40 percent of individuals and may include dementia, abnormalities of eye and facial muscle movements, headaches, seizures, loss of muscle control, memory loss, weakness, and vision problems.

Gastrointestinal symptoms may include diarrhea, weight loss, fatigue, weakness, and abdominal bleeding and pain. Fever, cough, anemia, heart and lung damage, darkening of the skin, and joint soreness may also be present. The disease is more common in men and neurological symptoms are more common in individuals who have severe abdominal disease. Rarely, neurological symptoms may appear without gastrointestinal symptoms and can mimic symptoms of almost any neurologic disease.

Treatment

The standard treatment for Whipple's disease is a prolonged course of antibiotics (up to two years), including penicillin and cefriaxone or doxycycline with hydroxychloroquine. Sulfa drugs (sulfonamides) such as sulfadizine or solfamethoxazole can treat neurological symptoms. Relapsing neurologic Whipple's disease (marked by bouts of worsening of symptoms) is sometimes treated with a combination of antibiotics and weekly injections of interferon gamma, a substance made by the body that activates the immune system.

Prognosis

Generally, long-term antibiotic treatment to destroy the bacteria can relieve symptoms and cure the disease. If left untreated, the disease is progressive and fatal. Individuals with involvement of the central nervous system generally have a worse prognosis and may be left with permanent neurologic disability. Deficits may persist and relapses may still occur in individuals who receive appropriate treatment in a timely fashion. Prognosis may improve with earlier recognition, diagnosis, and treatment of the disorder.


External links

NIH Gastrointestinal Disorders Topics


WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.



Articles on Whipple's disease


Topics related to Whipple's disease

See other topics, articles and terms related to Whipple's disease on WikiMD.

This article is a stub. YOU can help Wikimd by expanding it!



Health topics
A-Z health topics | Popular health topics

A |  B |  C |  D |  E |  F |  G |  H |  I |  J |  K |  L |  M | N |  O |  P |  Q |  R |  S |  T |  U |  V |  W |  X |  Y |  Z

Portals | Portal:Medicine

Medicines | Dentistry portal | Medications portal | Pharmacology portal | Psychiatry portal

Glossaries and dictionaries | Comprehensive dictionary of medicine

Glossary of medicine | Glossary of health topics | Anatomy | Diet | Pediatrics | Cardiology | Neurology | Pathology | Psychiatry | Obesity | Pharmacology | Rheumatology | Gynecology

WikiMD Resources for Whipple's disease

Articles

Most recent articles

Most cited

Review articles

Articles on Whipple's disease in N Eng J Med, Lancet, BMJ

Media Whipple's disease

Powerpoint slides

Podcasts and MP3's

Videos

Evidence Based Medicine

Cochrane Collaboration

Clinical Trials

Ongoing Trials on Whipple's disease

Trial results on Whipple's disease

Clinical Trials on Whipple's disease at Google

Books and news

Books on Whipple's disease

Whipple's disease in the news

Commentary Whipple's disease

Blogs on Whipple's disease

Patient Resources / Community

Patient resources

Discussion groups

Patient Handouts

Other resources

Social Media

Reddit
Quora.png
Pins
Instagram
YouTube videos
Flickr
Bing.png

W8MD Weight Loss, Sleep & MedSpa

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U |V | W | X | Y | Z

Ad. Tired of being overweight? W8MD's insurance weight loss program can HELP* | Lose weight King of Prussia, PA | Lose weight NYC | Lose weight NJ | Lose weight Philadelphia Advertise

Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer. * Individual results may vary for weight loss from our sponsors.

Our sponsors WikiMD is supported by W8MD weight loss, sleep and medical aesthetic centers.