17 demethoxy 17 allylaminogeldanamycin mesylate

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

17 demethoxy 17 allylaminogeldanamycin mesylate - the orally bioavailable mesylate salt of the 17 allylaminogeldanamycin (17 aag) small molecule inhibitor of several receptor protein tyrosine kinases with potential antiangiogenic and antineoplastic activities. Telatinib binds to and inhibits the vascular endothelial growth factor receptors (vegfrs) type 2 and 3, platelet derived growth factor receptor beta (pdgfrb) and c kit, which may result in the inhibition of angiogenesis and cellular proliferation in tumors in which these receptors are upregulated. These telatinib inhibited receptor protein tyrosine kinases are overexpressed or mutated in many tumor cell types and may play key roles in tumor angiogenesis and tumor cell proliferation. 17 aag is a synthetic analogue of the benzoquinone ansamycin antibiotic geldanamycin and has also been found to inhibit the molecular chaperone hsp90.

Up to date info

UpToDate

Latest research - 17 demethoxy 17 allylaminogeldanamycin mesylate

PubMed
Clinical trials

Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on 17 demethoxy 17 allylaminogeldanamycin mesylate for any updates.

 

17 demethoxy 17 allylaminogeldanamycin mesylate is part of WikiMD's free ^articles!

^17 demethoxy 17 allylaminogeldanamycin mesylate (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available