2-13c acetate

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2-13c acetate - the non-radioactive naturally occurring isotope of acetate, carbon c 13 acetate, with potential use for metabolic tumor imaging upon nuclear magnetic resonance (nmr) spectroscopy. Upon infusion, carbon c 13 acetate is taken up by cancer cells and is utilized by metabolic pathways in the tumor cell. Specifically, the tumor cells oxidize acetate, in the form of acetyl coenzyme a (acetyl-coa), in the citric acid cycle. Upon 13c-nmr, the metabolic phenotype of a tumor can be assessed. Certain alternative metabolic pathways are activated in tumor cells and use substrates other than glucose, such as acetate, for acetyl-coa production.

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