4 demethylcholesteryloxycarbonylpenclomedine

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

4 demethylcholesteryloxycarbonylpenclomedine - a cholesterol carbonate derivative of 4 demethylpenclomedine (dm pen) with potential antineoplastic alkylating activity. Upon intravenous administration of 4 demethylcholesteryloxycarbonylpenclomedine, the carbonium moiety binds to and alkylates dna at the n7 guanine position, thereby causing dna crosslinks. This prevents dna replication, inhibits cellular proliferation and triggers apoptosis. In addition, due to its lipophilic cholesteryl moiety this agent is able to cross the blood brain barrier (bbb) and therefore can be given intravenously compared to other alkylating agents that need to be given intra cranially.

Up to date info


Latest research - 4 demethylcholesteryloxycarbonylpenclomedine

Clinical trials

Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on 4 demethylcholesteryloxycarbonylpenclomedine for any updates.


4 demethylcholesteryloxycarbonylpenclomedine is part of WikiMD's free ^articles!

^4 demethylcholesteryloxycarbonylpenclomedine (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available