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64-cu-plerixafor - a radioconjugate labeled with the positron-emitting radioisotope, copper cu 64, and also composed of plerixafor, a bicyclam and hematopoietic stem cell-mobilizing agent that targets the chemokine receptor cxcr4, with tumor imaging potential using positron emission tomography (pet)/computed tomography (ct). Upon administration, the plerixafor moiety blocks the binding of stromal cell-derived factor-1alpha (sdf-1alpha or cxcl12) to the cellular receptor cxcr4. In turn, the cxcr4-expressing tumor cells can be visualized using pet/ct and the resulting images could be used to predict a tumor's response to certain treatments. The expression of cxcr4 on cancer cells has been correlated with increased tumor cell survival, tumor progression, and increased metastatic potential.

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on 64-cu-plerixafor for any updates.


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