AMG319

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AMG319

AMG319 (pronounced as A-M-G-Three-One-Nine) is a potent and selective small molecule inhibitor of PI3Kδ (Phosphoinositide 3-kinase delta). It is primarily used in the research of various cancer types, including leukemia and lymphoma.

Etymology

The term "AMG319" is a proprietary name given by the pharmaceutical company Amgen, which developed this molecule. The name does not have a specific etymology as it is a combination of the company's initials and a unique identifier number.

Usage

AMG319 is used in preclinical and clinical studies to inhibit the PI3Kδ pathway, which is often overactive in cancer cells. By blocking this pathway, AMG319 can potentially slow down or stop the growth of cancer cells. It is particularly used in the study of B-cell malignancies, such as chronic lymphocytic leukemia and non-Hodgkin lymphoma.

Related Terms

  • Phosphoinositide 3-kinases (PI3Ks): A family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which are often deregulated in cancer.
  • PI3Kδ inhibitor: A type of drug that blocks the action of PI3Kδ, a specific type of PI3K that is often overactive in cancer cells.
  • B-cell: A type of white blood cell that matures into plasma cells and produces antibodies.

See Also

External links

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