ATR kinase inhibitor VX-970

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

An inhibitor of ataxia telangiectasia and rad3-related (ATR) kinase, a DNA damage response kinase, with potential antineoplastic activity. ATR kinase inhibitor VX-970 selectively inhibits ATR kinase activity and prevents ATR-mediated signaling in the ATR-checkpoint kinase 1 (Chk1) signaling pathway. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis. In addition, VX-970 sensitizes tumor cells to chemo- and radiotherapy. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression, and survival; it is activated by DNA damage caused during DNA replication-associated stress.

Learn more about ATR kinase inhibitor VX-970

Latest research - ATR kinase inhibitor VX-970

Clinical trials

External links

Medicine icon
Medicine icon

This WikiMD article ATR kinase inhibitor VX-970 is a stub. If you are familiar with the topic ATR kinase inhibitor VX-970, you can help us. Paid editors welcome!


ATR kinase inhibitor VX-970 is part of WikiMD's free ^articles!

^ATR kinase inhibitor VX-970 (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available