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Information about Ketorolac

Ketorolac is a potent, short acting nonsteroidal antiinflammatory drug (NSAID) that is available in both parenteral and oral forms. 


Liver safety of Ketorolac

Ketorolac is generally given for a few days only, and has not been linked to instances of idiosyncratic drug induced liver disease in the published literature.

Mechanism of action of Ketorolac

Ketorolac tromethamine belongs to the acetic acid class of NSAIDs similar to diclofenac and etodolac.  Like other NSAIDs, ketorolac is a potent cyclo-oxygenase (Cox) inhibitor which blocks the formation of prostaglandins that are important in pain and inflammatory pathways. 

FDA approval information for Ketorolac

Ketorolac was approved in the United States in 1991 and current indications are limited to the short term management of moderately severe, acute pain.  Ketorolac is available in parenteral and oral forms in multiple generic forms and under the brand name Toradol

Dosage and administration for Ketorolac

The recommended dose is 60 mg intramuscularly or 30 mg intravenously initially, followed by 30 mg every 6 hours for up to 5 days.  An oral form is available in 10 mg tablets for switching from the parenteral form and is given every 6 to 8 hours, but continuation beyond 5 days is not recommended.  Ketorolac is available by prescription only and it is used largely for management of postoperative pain. 

Side effects of Ketorolac

Common side effects include gastrointestinal upset, nausea, headache and itching.

Nonsteroidal Antiinflammatory Drugs (NSAIDs)

Acetaminophen, Celecoxib, Diclofenac, Diflunisal, Etodolac, Fenoprofen, Flurbiprofen, Ibuprofen, Indomethacin, Ketoprofen, Ketorolac, Mefenamic Acid, Meloxicam, Nabumetone, Naproxen, Nimesulide, Oxaprozin, Phenylbutazone, Piroxicam, Rofecoxib, Sulindac, Tolmetin

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