Ad5-trail

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Ad5-trail - an adenovirus type 5 (ad5) encoding human tumor necrosis factor-related apoptosis-inducing ligand (trail), with potential apoptosis-inducing and antineoplastic activities. Upon administration of recombinant ad5 encoding trail, the adenovirus selectively infects tumor cells and expresses trail. The virally expressed trail binds to and activates its receptors trail receptor-1 (trail-r1, death receptor 4, dr4) and trail receptor-2 (trail-r2, death receptor 5, dr5), which subsequently activate caspases and induce apoptosis in trail-r1/r2-expressing tumor cells. The pro-apoptotic cell surface receptors trail-r1 and -r2, members of the tnf receptor family, are overexpressed by a variety of cancer cell types. Also see recombinant adenovirus 5 encoding tumor necrosis factor-related apoptosis-inducing ligand

Up to date info

UpToDate

Latest research - Ad5-trail

PubMed
Clinical trials

Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Ad5-trail for any updates.

 

Ad5-trail is part of WikiMD's free ^articles!

^Ad5-trail (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available