Atherogenesis

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Atherogenesis

Atherogenesis (pronunciation: /ˌæθəroʊˈdʒɛnɪsɪs/) is the process in which fatty deposits, or plaques, build up in the inner lining of arteries. This process can lead to atherosclerosis, a disease characterized by the hardening and narrowing of the arteries.

Etymology

The term "atherogenesis" is derived from the Greek words "athero" (gruel) and "genesis" (origin, creation). It refers to the creation of a gruel-like substance, which is the fatty plaque that accumulates in the arteries.

Process

Atherogenesis begins when the innermost layer of the artery, the endothelium, becomes damaged. This damage can be caused by various factors, such as high blood pressure, smoking, or high levels of cholesterol in the blood. Once the endothelium is damaged, cholesterol and other fats can begin to accumulate at the site of injury, forming a fatty streak. Over time, this fatty streak can grow into a larger plaque, which can obstruct blood flow and lead to heart disease.

Related Terms

  • Endothelium: The innermost layer of the artery, which can become damaged and initiate atherogenesis.
  • Atherosclerosis: A disease characterized by the hardening and narrowing of the arteries, which can result from atherogenesis.
  • Cholesterol: A type of fat that can accumulate in the arteries and contribute to atherogenesis.
  • Plaque: A deposit of fats, cholesterol, and other substances that can build up in the inner lining of the arteries during atherogenesis.
  • Heart Disease: A broad term for a range of diseases that affect the heart, which can result from atherogenesis.

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