CHOP regimen
CHOP Regimen
The CHOP regimen (pronounced as /ʧɒp/), is a chemotherapy treatment protocol primarily used for non-Hodgkin lymphoma. The acronym CHOP stands for the combination of four different drugs: Cyclophosphamide, Hydroxydaunorubicin (also known as Doxorubicin), Oncovin (also known as Vincristine), and Prednisone.
Etymology
The term "CHOP regimen" is derived from the initial letters of the chemical names of the drugs used in the treatment. The regimen was first introduced in the 1970s and has since been a standard treatment for non-Hodgkin lymphoma.
Components
- Cyclophosphamide: An alkylating agent that prevents cell division by cross-linking DNA strands and decreasing DNA synthesis.
- Hydroxydaunorubicin (Doxorubicin): An anthracycline antibiotic that works by intercalating DNA, disrupting the function of enzymes involved in DNA replication.
- Oncovin (Vincristine): A vinca alkaloid that inhibits mitosis in metaphase through its interaction with tubulin.
- Prednisone: A corticosteroid that works by suppressing the immune system and inflammation.
Usage
The CHOP regimen is used to treat non-Hodgkin lymphoma, including diffuse large B-cell lymphoma. It is often combined with other treatments, such as Rituximab, an anti-CD20 monoclonal antibody, in a regimen known as R-CHOP.
Related Terms
See Also
External links
- Medical encyclopedia article on CHOP regimen
- Wikipedia's article - CHOP regimen
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