Lynch
Lynch Syndrome
Lynch Syndrome (/'lɪntʃ 'sɪndroʊm/), also known as Hereditary Nonpolyposis Colorectal Cancer (HNPCC), is a type of inherited cancer syndrome associated with a genetic predisposition to different cancer types. This syndrome is named after Henry T. Lynch, the physician who first described it.
Etymology
The term "Lynch Syndrome" is derived from the name of Dr. Henry T. Lynch, who first described this condition in the late 1960s. The term "Hereditary Nonpolyposis Colorectal Cancer" (HNPCC) is a descriptive term indicating the hereditary nature of the condition and its primary manifestation in the form of colorectal cancer without the presence of numerous polyps.
Definition
Lynch Syndrome is a genetic disorder that increases the risk of many types of cancer, particularly colorectal cancer and endometrial cancer. It is caused by mutations in genes responsible for repairing errors in DNA.
Symptoms
People with Lynch Syndrome may have:
- Colon cancer at a young age
- A family history of colon cancer
- A history of endometrial or ovarian cancer
- Other related cancers, including stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, and skin
Diagnosis
Diagnosis of Lynch Syndrome involves a detailed family history, genetic testing for mutations in the DNA mismatch repair genes, and clinical criteria such as the Amsterdam Criteria or the Revised Bethesda Guidelines.
Treatment
Treatment for Lynch Syndrome involves regular screenings for early detection of cancer, as well as preventative measures such as a healthy diet, regular exercise, and possibly surgery or medication.
Related Terms
External links
- Medical encyclopedia article on Lynch
- Wikipedia's article - Lynch
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